331 results found
    1. Developmental Biology
    2. Evolutionary Biology

    Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network

    Joaquín Letelier, Lorena Buono ... Juan R Martínez-Morales
    Depletion of vsx genes in zebrafish confirms a conserved role in bipolar cells specification across vertebrates, but do not interfere with the formation of the neural retina domain, which reveal an unexpected robustness of the genetic network sustaining the retina.
    1. Cell Biology
    2. Genetics and Genomics

    Differential requirements for mitochondrial electron transport chain components in the adult murine liver

    Nicholas P Lesner, Xun Wang ... Prashant Mishra
    Animal models reveal that mitochondrial complex I is dispensable for homeostatic functions of the mouse liver.
    1. Neuroscience

    CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles

    Brian D Mueller, Sean A Merrill ... Erik M Jorgensen
    The Caenorhabditis elegans presynapse contains two pools of synaptic vesicles at the active zone, coupled to either neuronal-type or muscle-type calcium channels, and to different docking machinery.
    1. Plant Biology

    Competence for transcellular infection in the root cortex involves a post-replicative, cell-cycle exit decision in Medicago truncatula

    Morgane Batzenschlager, Beatrice Lace ... Thomas Ott
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Cell Biology
    2. Neuroscience

    Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer’s Disease

    Vibhavari Aysha Bansal, Jia Min Tan ... Toh Hean Ch’ng
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Cancer Biology

    The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism

    Ganesan Senthil Kumar, Ezgi Gokhan ... Rebecca Page
    Building on previous work (Booth et al, 2014), we show how two mitotic phosphatases are formed, how they are regulated by opposing kinases during the cell cycle and reveal a novel opportunity for the development of cancer therapeutics.
    1. Biochemistry and Chemical Biology

    Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

    Gabriella O Estevam, Edmond M Linossi ... James S Fraser
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Evolutionary Biology
    2. Genetics and Genomics

    Cell-type-specific cis-regulatory divergence in gene expression and chromatin accessibility revealed by human-chimpanzee hybrid cells

    Ban Wang, Alexander L Starr, Hunter B Fraser
    Exploring tissue-specific regulation of gene expression with human-chimpanzee hybrid cells helps us understand how life evolves and what makes us human.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression

    Jie Lin, Yujian Wen ... Hao Zhu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Developmental Biology

    Skeletal Muscle Satellite Cells Co-Opt the Tenogenic Gene Scleraxis to Instruct Regeneration

    Yun Bai, Tyler Harvey ... Chen-Ming Fan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing

Refine your results by:

Type
Research categories