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Molecular insights to phytochrome activation and signal transduction over long distances enable the allosteric regulation of enzymatic effectors.

Plant meristem size and shape is controlled by two intertwined regional feedback signals that are mediated by secreted peptides.

The first structure of a bacteriophage-encoded S-adenosyl methionine degrading enzyme was solved and demonstrated to catalyze a unimolecular lyase reaction occurring at the domain interface of a trimeric structure.

Self-reactive B cells downregulate the IgM but not the IgD B cell receptor, and this serves as a critical tolerance mechanism because IgD is less sensitive to bona fide endogenous antigens than IgM.

Identification of a new family of stress-induced plant signalling peptides and their cognate receptor.

High triiodothyronine levels lead to a broad rewiring of the liver transcriptome, which mostly occurs downstream of the liver clock machinery itself, thus suggesting that daytime critically affects thyroid hormone action in the liver.

In addition to the well-established involvement of descending neural tracts, the left-right side-specific endocrine mechanism may contribute to signaling from injured brain to spinal motor circuits.

The GPCR-G protein coupling map and selectivity insights will catalyze advances in receptor research, cellular signaling, and drug discovery exploiting G protein signaling bias to design safer drugs.

Targeted manipulation of the locus coeruleus noradrenaline circuitry combined with extensive transcriptomic analyses in the mouse hippocampus reveal a unique set of noradrenaline-dependent, stress-related genes and point to astrocytic engagement.

Mutant and gene expression analyses shows that phytohormones and mobile transcription factors interact to coordinate organ formation with stem cell maintenance in the plant shoot meristem.