503 results found
    1. Cell Biology
    2. Developmental Biology

    A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging

    Neta Erez et al.
    A nuclear Non-stop identity complex (NIC) supervises enterocyte (EC) identity, preserves tissue homeostasis, and prevents premature aging by maintaining EC-specific gene expression, silencing non-relevant programs, and safeguarding large-scale nuclear organization.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    NAD+ enhances ribitol and ribose rescue of α-dystroglycan functional glycosylation in human FKRP-mutant myotubes

    Carolina Ortiz-Cordero et al.
    The combined use of NAD+ with ribitol or ribose potentiates the rescue of α-dystroglycan functional glycosylation in FKRP-mutant patient-specific iPSC-derived myotubes, representing potential novel treatments for FKRP muscular dystrophies.
    1. Developmental Biology

    A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

    Qiuyu Guo et al.
    β-Catenin-mediated expansion of nephron progenitors is independent of direct β-catenin/chromatin engagement, while progenitor induction proceeds with a β-catenin-driven switch of repressive TCFL1/TCFL2 to activating TCF7/LEF1 factors on transcriptionally poised enhancers.
    1. Developmental Biology
    2. Plant Biology

    Epigenetic reprogramming rewires transcription during the alternation of generations in Arabidopsis

    Michael Borg et al.
    Epigenetic reprogramming of the distinct repressive marks H3K27me3 or H3K9me2 guides the transition between the haploid and diploid life forms that encompass the life cycle of land plants.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes

    Michelle C Ward et al.
    Cellular stress in a disease-relevant cell type uncovers novel genetic effects on gene expression, which is likely relevant for disease.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An interbacterial DNA deaminase toxin directly mutagenizes surviving target populations

    Marcos H de Moraes et al.
    Interbacterial interactions can promote mutagenesis, and possibly adaptation, when intoxicated cells survive exposure to type VI secretion-delivered DNA deaminase toxins.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Bacterial Warfare: Toxins, mutations and adaptations

    Maarten De Jong, Neal M Alto
    The toxins that some bacteria secrete to kill off rival species can also generate mutations that help toxin-resistant populations adapt to new environments.
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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A nuclease- and bisulfite-based strategy captures strand-specific R-loops genome-wide

    Phillip Wulfridge, Kavitha Sarma
    BisMapR reveals strand-specific R-loops with high resolution at small-scale genomic features including bidirectionally transcribed promoters and enhancers.
    1. Cancer Biology
    2. Genetics and Genomics

    Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells

    Iris E Glykofridis et al.
    Knocking out Folliculin (FLCN) in human renal epithelial cells activates STAT1/2-mediated gene expression, independent of interferon, uncovering a tissue-specific process potentially relevant in the cancer syndrome Birt-Hogg-Dubé (BHD).
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Intronic enhancer region governs transcript-specific Bdnf expression in rodent neurons

    Jürgen Tuvikene et al.
    An evolutionarily conserved neuron-specific and stimulus-dependent enhancer region downstream of the Bdnf exon III regulates the expression of Bdnf transcripts starting from the upstream 5' exons.

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