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Biochemistry and Chemical Biology
Cell Biology
iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
Ioanna Oikonomidi, Emma Burbridge ... Colin Adrain
Secretion of the inflammatory cytokine TNF requires a protein called iTAP/FrmD8, which controls the cell surface stability of the TNF shedding machinery, iRhom2 and TACE/ADAM17.
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