1,001 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites

    Seyi Falekun et al.
    Malaria parasites have simplified and adapted their mitochondrial metabolism to lack fatty acid synthesis but retain an unusual acyl carrier protein required for stability of the core iron-sulfur cluster biogenesis complex.
    1. Neuroscience

    Auditory sensory deprivation induced by noise exposure exacerbates cognitive decline in a mouse model of Alzheimer’s disease

    Fabiola Paciello et al.
    Central damage and sensory deprivation caused by noise-induced hearing loss in the pre-symptomatic Alzheimer's disease (AD) phase can compromise auditory cortex-hippocampal circuitry, targeting common pathogenetic pathways, thereby accelerating onset and progression of AD phenotype.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development

    Amy Reilein et al.
    Somatic stem and niche cells in the Drosophila ovary develop from common precursors through regulated proliferative expansion, followed by acquisition of position-specific behaviors, rather than through rigid early specification events.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction

    Fabio Da Silva et al.
    Lineage tracing and genetic experiments resolve a long-standing controversy by showing that retinoic acid signaling is active in cardiomyocytes, both during development and after myocardial infarction, and protects damaged hearts from apoptosis.
    1. Evolutionary Biology

    Decreased recent adaptation at human mendelian disease genes as a possible consequence of interference between advantageous and deleterious variants

    Chenlu Di et al.
    Harmful genetic variants at mendelian disease genes slow down adaptation, by interfering with the spread of adaptive variants in a population.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size

    Alessandro Bonfini et al.
    The nutrient composition of food alters both the size of gut epithelial cells and the ability of the stem cell niche to control tissue turnover, resulting in changes in size at the organ level.
    1. Genetics and Genomics
    2. Neuroscience

    The structure of behavioral variation within a genotype

    Zachary Werkhoven et al.
    Multidimensional analysis of data from high-throughput behavioral assays reveals many independent axes of behavioral variation among inbred animals reared in the same environment.
    1. Neuroscience

    Early life experience sets hard limits on motor learning as evidenced from artificial arm use

    Roni O Maimon-Mor et al.
    Biological- or artificial-arm experience during early development has a significant effect on artificial-arm motor control in adulthood, providing evidence for limited sensorimotor plasticity beyond childhood.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Circular RNA repertoires are associated with evolutionarily young transposable elements

    Franziska Gruhl et al.
    Evolutionary analyses suggest that most mammalian circRNAs did not emerge from common ancestral circRNA precursors, arguing against widespread functional conservation.
    1. Genetics and Genomics

    Utility of polygenic embryo screening for disease depends on the selection strategy

    Todd Lencz et al.
    Preimplantation screening of embryos using polygenic risk scores may substantially reduce risk for a given complex disease, but this effect depends on several quantifiable factors and raises significant ethical issues.

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