109 results found
    1. Developmental Biology
    2. Evolutionary Biology

    The alternative regenerative strategy of bearded dragon unveils the key processes underlying vertebrate tooth renewal

    Lotta Salomies et al.
    Analysis of bearded dragon model reveals a novel tooth replacement strategy that demonstrates the critical importance of epithelial patterning, cell migration, and putative stem cell functional specialization in tissue regeneration.
    1. Cancer Biology

    Mutationally-activated PI3’-kinase-α promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase

    J Edward van Veen et al.
    Two of the most commonly mutated growth factor pathways induce a deadly feature of lung adenocarcinoma.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes

    Lauren N Booth et al.
    Nematode hermaphroditism has co-evolved with a self-sperm sensing mechanism that protects hermaphrodites from the detrimental effects of mating with males.
    1. Developmental Biology
    2. Neuroscience

    Lmx1b is required at multiple stages to build expansive serotonergic axon architectures

    Lauren J Donovan et al.
    A continuously expressed LIM HD factor, Lmx1b, acts at successive stages to orchestrate the progressive morphological maturation of a long-range profusely arborized neuromodulatory axonal projection pathway.
    1. Developmental Biology

    Critical roles of ARHGAP36 as a signal transduction mediator of Shh pathway in lateral motor columnar specification

    Heejin Nam et al.
    Shh, produced by postmitotic spinal neurons, plays crucial roles in the specification of the lateral motor column of the spinal cord through ARHGAP36.
    1. Cancer Biology
    2. Cell Biology

    A positive feedback loop between Myc and aerobic glycolysis sustains tumor growth in a Drosophila tumor model

    Kenneth Kin Lam Wong et al.
    Specific molecular links that orchestrate growth signals and metabolic reprogramming to achieve tumorigenesis are identified as potential metabolic vulnerabilities in cancer treatment.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity

    Jeehae Park et al.
    The sharp expression pattern driven by a classic, simple animal enhancer is determined by multiple molecular mechanisms, not only cooperative binding of the activating transcription factor as was previously thought.
    1. Developmental Biology
    2. Evolutionary Biology

    Evolution of limb development in cephalopod mollusks

    Oscar A Tarazona et al.
    Cuttlefish embryos reveal that cephalopod mollusks evolved specialized arms and tentacles by activating the same genetic circuits that control development of limbs in arthropods and vertebrates.
    1. Developmental Biology

    The Hox transcription factor Ubx stabilizes lineage commitment by suppressing cellular plasticity in Drosophila

    Katrin Domsch et al.
    The Hox transcription factor Ultrabithorax (Ubx) represses alternative gene programs during lineage development by lineage-specific Polycomb protein complex retention at Ubx-targeted chromatin sites.
    1. Cell Biology
    2. Computational and Systems Biology

    Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

    Nona Farbehi et al.
    Comprehensive scRNA-seq analysis of cardiac stromal cells in healthy and injured hearts reveals novel cell types and non-linear cell dynamics, providing new insights into cardiac inflammation, fibrosis and repair.

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