TALE homeodomain transcription factors have been independently recruited to regulate gametophyte to sporophyte transitions in two complex multicellular eukaryotic supergroups, land plants in Archaeplastida and brown algae in Chromalveolata.

The ancestral mechanism to activate diploid gene expression via homeodomain transcription factors was retained in liverworts, an early diverging land plant lineage, and subsequently co-opted during evolution of the diploid sporophyte body.

Gamete-derived three-amino-acid-loop-extension homeodomain proteins activate zygote development in a strikingly similar manner between basal land plants and green algae, indicating an ancestral role of these transcription factors in green plants.

Combining mouse genetic, behavioral, and electrophysiological approaches revealed that a transcription factor is required to shape touch neurons' distal projections in the skin while dispensable for their survival and specification.

Expression of Pitx2c at the onset of gastrulation drives convergence and extension movements in the zebrafish embryo by promoting downstream pathways affecting chemokine signaling, integrin-ECM interactions, and planar cell polarity components.

Interactions between Hox and TALE genes, which generate bilaterally symmetrical body plans, originated in early multicellular animals.

TALE transcription factors bind different genomic motifs and function together with different protein partners at different stages of zebrafish embryogenesis.

The collinear activation of a subset of posterior Hox genes is responsible for establishing a Wnt/T activity gradient that is required to generate the complete body axis, and hence the full set of segments within a vertebrate embryo.

Discovering that Hoxb1 acts as a repressor of cardiac differentiation on second heart field progenitor cells helps us to understand the etiology of congenital heart defects such as atrioventricular septal defects.

The RNA binding protein PTBP1 controls an extensive program of alternative splicing in embryonic stem cells, one function of which is to repress neuronal transcriptional programs.