TANGO2 emerges as a key regulator of fatty acid metabolism by likely affecting acyl-CoA production and utilization.

TANGO1 creates a sub-compartment at the endoplasmic reticulum, to segregate and export fully assembled bulky cargoes.

Building on previous work (Tang et al., 2015), novel ESCRT-III subunit Snf7 auto-activation mutants are used to reveal two parallel ubiquitin-dependent pathways during multivesicular endosome biogenesis.

Curves and corners are separately encoded by neurons clustered into functional domains in macaque V4.

Inactivation of SURF4 leads to impaired secretion of PCSK9 and apolipoproteins resulting in low plasma cholesterol without detrimental consequences to the liver.

TANGO1 functions as a linactant filament to stabilize shallow COPII-coated buds, and after which membrane tension regulation, possibly mediated by TANGO1-controlled membrane fusion, facilitates bud elongation for procollagen export.

Unsupervised cluster analysis identified similar groups of children in different cohorts, with distinct developmental patterns of immunorespiratory health, asthma and allergy.

The first human TANGO1-associated syndromal disease manifests as impaired collagen secretion, highlighting the importance of TANGO1 in human pathophysiology.

A novel population of hematopoietic cells unmasked by mTORC1 inactivation reveals a new mechanism of innate immune tolerance and a new consequence of defective hematopoiesis.

Regulation of cellular properties such as ligand secretion and migratory ability through changes in the cytoskeleton mediated by a Wnt5a–Ror2–Vangl2 axis is a major determinant of alveolar formation.