Xin-Zi Tang, Lieselotte S M Kreuk ... Christopher D C Allen
Lung interstitial macrophages are strategically positioned underneath the bronchial airway epithelium and enriched at airway bifurcations for immunosurveillance of the conducting airway lumen and the initiation of adaptive immune responses.
A proximity labeling approach defines germ granule proteome in Caenorhabditis elegans, and identifies LOTUS domain proteins as key regulators of germ granule assembly.
An insect-transmissible plant pathogen, Bursaphelenchus xylophilus, uniquely excavates hypoxia to increase vector capacity via Muc91C-enhanced elasticity of tracheal tubes.
Curvature-preferring neurons in monkey V4 cluster into 0.5-mm patches, which highlights the importance of curvature detection in visual object recognition and the key functional role of V4 in this process.
Integrative structural analyses of human insulin degradingenzyme (IDE) reveal how IDE selectively degrades peptides that form toxicaggregates, which guides IDE-based therapeutic innovations to treat diabetesand Alzheimer's disease.
Rui Tang, Christopher W Murray ... Monte M Winslow
A novel reporter system that employs cell surface antigen-nanobody pairing enables physical interaction-dependent labeling and functional modification between diverse cell types.
Two-photon imaging reveals super-sparse responses to natural images in primate V1, which carry sufficient information for discrimination of the input natural images with high accuracy.
Lineage analysis reveals that cardiac neural crest contributes to cardiomyocytes across vertebrates and consistent with this, the neural crest gene regulatory program is reactivated upon heart regeneration in zebrafish.
