711 results found
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon, Sarah E Lower ... Jing-Ke Weng
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences

    Jeffrey Y Lee, Peter AC Wing ... Ilan Davis
    Single-molecule analysis of SARS-CoV-2 RNA identifies significant heterogeneity in cellular viral RNA levels and highlights slower replication kinetics for the Alpha variant compared to the Victoria strain.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    MERS-CoV spillover at the camel-human interface

    Gytis Dudas, Luiz Max Carvalho ... Trevor Bedford
    MERS-CoV infections in the Arabian Peninsula are the result of several hundred spillover events from viruses circulating in camels into the human population.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution

    John Huddleston, John R Barnes ... Trevor Bedford
    The combination of phenotypic measures of antigenic drift and genotypic measures of functional constraint improves the accuracy of long-term seasonal influenza A/H3N2 forecasts.
    1. Neuroscience

    Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms

    Christopher Bell, Lukas Kilo ... Stefanie Ryglewski
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    The metabolome of Mexican cavefish shows a convergent signature highlighting sugar, antioxidant, and Ageing-Related metabolites

    J Kyle Medley, Jenna Persons ... Nicolas Rohner
    Metabolomics data reveals unique metabolic insights into how cavefish adapt to nutrient limited environments while staying healthy.
    1. Neuroscience

    Brain structure and function link to variation in biobehavioral dimensions across the psychopathological continuum

    Jasper van Oort, Alberto Llera ... Philip FP van Eijndhoven
    The multimodal linked independent component analysis promotes a more integrative understanding of transdiagnostic mechanisms of psychopathology.
    1. Cell Biology
    2. Physics of Living Systems

    Flagellar energetics from high-resolution imaging of beating patterns in tethered mouse sperm

    Ashwin Nandagiri, Avinash Satish Gaikwad ... Ranganathan Prabhakar
    Calculations of flagellar energetics from beating patterns in sperm reveal that internal dissipation by dynein motors and other passive structures within the flagellum significantly exceeds external hydrodynamic dissipation.
    1. Cell Biology

    Surface curvature and basal hydraulic stress induce spatial bias in cell extrusion

    Cheng-Kuang Huang, Xianbin Yong ... Chwee Teck Lim
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing

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