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DYT1 dystonia increases risk taking in humans
David Arkadir et al.
Patients with DYT1 dystonia show aberrant risk-aversion in a simple decision-making task, in accordance with predictions of a reinforcement learning model of corticostriatal trial-and-error learning.
Instructed knowledge shapes feedback-driven aversive learning in striatum and orbitofrontal cortex, but not the amygdala
Lauren Y Atlas et al.
While the striatum and orbitofrontal cortex learn about threats through verbal warnings, the amygdala learns only from direct experience, suggesting that the amygdala forms part of a specialized threat detection system.
Computational and Systems Biology
Dopamine role in learning and action inference
A mathematical model describes the function of dopaminergic neurons in both learning and action planning.
Correction: Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome
Yilin Kang et al.
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics
SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets
Palur V Raghuvamsi et al.
SARS-CoV-2 spike protein binding to receptor angiotensin-converting enzyme 2 allosterically enhances furin proteolysis at distal S1/S2 cleavage sites.
Genetics and Genomics
A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe
Benjamin W Okaty et al.
neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment
Leilei Zhong et al.
A newly identified adipose lineage cell population, MALP, regulates marrow vasculature and osteogenesis in bone.
Retinal oxygen supply shaped the functional evolution of the vertebrate eye
Christian Damsgaard et al.
Multiple respiratory and vascular mechanisms have recurrently evolved across the vertebrates to alleviate the oxygen diffusion limitations inherent to the morphology of the retina.
Signal categorization by foraging animals depends on ecological diversity
David William Kikuchi et al.
In richer, more even communities, foragers form broad categories among their food resources that can select for convergence among signals, including mimetic resemblances.
Expansion of the fatty acyl reductase gene family shaped pheromone communication in Hymenoptera
Michal Tupec et al.
A fatty acyl reductase gene family expansion in the Hymenoptera crown group led to recruitment of novel pheromone-biosynthetic enzymes and is linked to evolution of pheromone marking behavior.
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