155 results found
    1. Genetics and Genomics
    2. Neuroscience

    Dissection of central clock function in Drosophila through cell-specific CRISPR-mediated clock gene disruption

    Rebecca Delventhal et al.
    Through novel, cell-specific CRISPR tools to disrupt molecular clock genes, it was revealed that circadian rhythms are coordinated through a network, rather than by the clock of 'master regulatory' neurons.
    1. Neuroscience

    Neuron-specific knockouts indicate the importance of network communication to Drosophila rhythmicity

    Matthias Schlichting et al.
    Network silencing experiments and cell-specific CRISPR/Cas9 knockouts suggest that network communication is necessary for generating robust rhythms within the clock neuron network.
    1. Neuroscience

    Electrocorticographic dissociation of alpha and beta rhythmic activity in the human sensorimotor system

    Arjen Stolk et al.
    Direct cortical recordings in humans link the spectral structure of local field potentials to inhibition/disinhibition mechanisms coordinating sensorimotor neuronal populations during movement imagery.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

    Timo Vögtle et al.
    Heparan sulfates in the vessel wall bind and regulate signaling from the megakaryocyte/platelet-specific inhibitory receptor G6b-B, a critical regulator of platelet homeostasis.
    1. Ecology
    2. Evolutionary Biology

    Reduced metabolism supports hypoxic flight in the high-flying bar-headed goose (Anser indicus)

    Jessica U Meir et al.
    Measurements of bar-headed geese flying in a wind tunnel in hypoxia reveal that these birds sustain aerobic flight at high altitude via a reduction in metabolism.
    1. Neuroscience

    The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm

    Thomas Michael Ernst et al.
    Pronounced cerebellar activation during unexpected omission of a potentially harmful event suggests that the cerebellum has to be added to the neural network processing prediction errors underlying emotional associative learning.
    1. Neuroscience

    Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy

    Ying Sun et al.
    Deep brain calcium imaging reveals the abnormal neuronal activity patterns of the amygdala GABAergic neurons in an animal model of human sleep disorder narcolepsy.
    1. Cancer Biology
    2. Cell Biology

    The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells

    Shaheen Kabir et al.
    Targeting the CRL5 ubiquitin ligase complex in combination with CDK9 or MCL1 inhibition could combat innate and acquired resistance of cancer cells to MCL1-targeting therapeutics.
    1. Structural Biology and Molecular Biophysics

    Ternary structure of the outer membrane transporter FoxA with resolved signalling domain provides insights into TonB-mediated siderophore uptake

    Inokentijs Josts et al.
    The crystal structure of a ternary complex of a TonB-dependent transporter containing a signalling domain, bound to siderophore as well as TonB, provides mechanistic insights into siderophore uptake and signalling.
    1. Cell Biology
    2. Developmental Biology

    Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration

    Joana R Carvalho et al.
    Analysis of axial polarity distributions shows that Wnt5a regulates collective cell migration in vivo by stabilizing vinculin at adherens junctions and fine-tuning mechanocoupling between neighbouring cells.

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