Through novel, cell-specific CRISPR tools to disrupt molecular clock genes, it was revealed that circadian rhythms are coordinated through a network, rather than by the clock of 'master regulatory' neurons.
Direct cortical recordings in humans link the spectral structure of local field potentials to inhibition/disinhibition mechanisms coordinating sensorimotor neuronal populations during movement imagery.
Pronounced cerebellar activation during unexpected omission of a potentially harmful event suggests that the cerebellum has to be added to the neural network processing prediction errors underlying emotional associative learning.
The crystal structure of a ternary complex of a TonB-dependent transporter containing a signalling domain, bound to siderophore as well as TonB, provides mechanistic insights into siderophore uptake and signalling.
Analysis of axial polarity distributions shows that Wnt5a regulates collective cell migration in vivo by stabilizing vinculin at adherens junctions and fine-tuning mechanocoupling between neighbouring cells.