Many disorders are characterized by underlying abnormalities in network connectivity which, though difficult to address with explicit training procedures, can be directly targeted through covert neurofeedback.
Florian Heigwer, Christian Scheeder ... Michael Boutros
Genetic interaction analysis by combinatorial genetic perturbation and high-throughput imaging maps time- and context-dependent crosstalk between signaling pathways.
Structural and functional analysis reveals the mechanistic basis for mammalian target of rapamycin (mTOR)-dependent roles of DEP domain-containing mTOR interacting protein (DEPTOR) in cancer and metabolic regulation.
The hippocampus demonstrates flexible coding during memory encoding, prioritizing either distance or time information based on the specific requirements of the experiment.
William F Podlaski, Alexander Seeholzer ... Tim P Vogels
The ion channel genealogy resource is a comprehensive and intuitive comparison tool for ion channel models and experimental data, helping to visualize their similarity and function to facilitate better experimentally-constrained modeling.
A novel neural mechanism for precise, unbiased estimation of time intervals in the thalamus of electric fish is likely used for computing distance between object encounters.
Deletion of delta-tubulin or epsilon-tubulin in human cells results in loss of centriolar triplet microtubules and defects in centriole structure and inheritance.
RNF213 is a giant E3 ligase with a dynein-like core and a unique ubiquitination mechanism that proceeds in a RING-independent manner and is linked with the Moyamoya disease.
GABAergic parvalbumin-expressing 'orchid cells' of the medial septum selectively target GABAergic neurons in connected extra-hippocampal areas of the mouse, providing rhythmically bursting inhibitory input at the peak of hippocampal 5-12 Hz theta oscillatory cycles.
Advanced genetics and imaging reveal wiring logic underlying the olfactory map organization in the developing fruit fly brain, and strategies employed by projection neurons to target dendrites to specific locations in a timely manner.
