534 results found
    1. Immunology and Inflammation

    Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry

    Valeria Ramaglia et al.
    Imaging mass cytometry simultaneously lights up distinct immune cells in the brain.
    1. Immunology and Inflammation

    B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota

    Lieselotte SM Kreuk et al.
    Microbial-sensing TLRs drive responses to the microbiota, while nucleic-acid sensing TLRs control responses to endogenous ligands, revealing novel regulation of B-1a responses through integrated BCR/TLR mediated activation.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2

    Rosa María Marión et al.
    Telomeric TRF1 controls the transcriptional programmes of pluripotent stem cells by recruiting PRC2 to pluripotency and differentiation genes by controlling the expression of those gene sites and the binding of TERRA RNAs to them.
    1. Microbiology and Infectious Disease

    Nanoscale organization of rotavirus replication machineries

    Yasel Garcés Suárez et al.
    Super-resolution microscopy reveals, at nanometric-scale, the highly organized protein structure of viroplasms, the viral factories used by rotavirus to replicate its genome and assemble new viral particles.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    PHLPP1 counter-regulates STAT1-mediated inflammatory signaling

    Ksenya Cohen Katsenelson et al.
    Uncovering a mechanism for how inflammatory signaling is opposed by a phosphatase identifies a potential druggable target to treat E. coli sepsis.
    1. Neuroscience

    The perception and misperception of optical defocus, shading, and shape

    Scott WJ Mooney et al.
    The human visual system uses sharp edges to distinguish a smooth, shaded surface from a surface blurred by optical defocus.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

    Rachel A Gottschalk et al.
    Inflammatory dynamics are tailored to bacterial class through macrophage integration of microbial stimuli and cytokine feedback.
    1. Cell Biology

    Type-I myosins promote actin polymerization to drive membrane bending in endocytosis

    Hetty E Manenschijn et al.
    Monomeric myosins can stimulate growth of actin filaments under load.
    1. Developmental Biology
    2. Genetics and Genomics

    A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes

    Joo Lee et al.
    First comprehensive genetic analysis of a Myt1 family protein reveals that neurogenesis requires direct repression of non-neuronal identities by the Myt1 family protein through MuvB co-repressor complex.
    1. Cell Biology
    2. Physics of Living Systems

    Metabolic constraints drive self-organization of specialized cell groups

    Sriram Varahan et al.
    In a developing yeast colony, cells go from homogeneous states to spatially organized, specialized metabolic states, and the new metabolic states depend on resources produced by the original state.

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