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    1. Cancer Biology
    2. Genetics and Genomics

    Circulating small extracellular vesicle RNA profiling for the detection of T1a stage colorectal cancer and precancerous advanced adenoma

    Li Min, Fanqin Bu ... Shutian Zhang
    Whole-transcriptomic profiling of circulating small extracellular vesicle RNA facilitates the detection of T1a stage colorectal cancer and precancerous advanced adenoma.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Sir2 phosphorylation through cAMP-PKA and CK2 signaling inhibits the lifespan extension activity of Sir2 in yeast

    Woo Kyu Kang, Yeong Hyeock Kim ... Jeong-Yoon Kim
    The deacetylase Sir2 fine-tunes transcription of PMA1 and other aging related genes in a cAMP-PKA and CK2 signaling dependent manner.
    1. Structural Biology and Molecular Biophysics

    Folding behavior of a T-shaped, ribosome-binding translation enhancer implicated in a wide-spread conformational switch

    My-Tra Le, Wojciech K Kasprzak ... Anne E Simon
    Folding and unfolding pathways are described for a ribosome-binding 3' cap-independent translation enhancer at the center of a conformational rearrangement that is implicated in the transition from translation to replication of an RNA virus.
    1. Developmental Biology
    2. Plant Biology

    Root-specific theanine metabolism and regulation at the single-cell level in tea plants (Camellia sinensis)

    Shijia Lin, Yiwen Zhang ... Zhaoliang Zhang
    A single-cell RNA sequencing reveals cell heterogeneity of secondary metabolism in tea plant root and a proposed model in which the theanine biosynthesis pathway occurs via multicellular compartmentation.
    1. Cell Biology

    A viral fusogen hijacks the actin cytoskeleton to drive cell-cell fusion

    Ka Man Carmen Chan, Sungmin Son ... Daniel A Fletcher
    A viral fusogen drives cell-cell fusion by hijacking the actin machinery to directly couple actin assembly with a short fusogenic ectodomain.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Vibrio cholerae’s ToxRS bile sensing system

    Nina Gubensäk, Theo Sagmeister ... Tea Pavkov-Keller
    The sensory regulatory system of the cholera causative involves the detection of bile acids by direct interaction with the inner membrane protein complex formed by ToxR and ToxS, thereby inducing concentration-dependent structural changes.
    1. Cell Biology

    Glucose intake hampers PKA-regulated HSP90 chaperone activity

    Yu-Chen Chen, Pei-Heng Jiang ... Shu-Chun Teng
    Food overconsumption impairs cellular protein folding through a novel aging-related signaling pathway.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq

    Elliott Swanson, Cara Lord ... Peter J Skene
    Simultaneous multimodal measurement of chromatin accessibility, gene expression, and protein expression provides a unified view of the molecular underpinnings of immune cell state in health and disease.
    1. Neuroscience

    An observational treatment study of metacognition in anxious-depression

    Celine Ann Fox, Chi Tak Lee ... Claire M Gillan
    Improvement in levels of anxious-depression corresponds with increased confidence in performance among individuals receiving mental health treatment within a large longitudinal dataset.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    MAF1 represses CDKN1A through a Pol III-dependent mechanism

    Yu-Ling Lee, Yuan-Ching Li ... Ming-Ta Hsu
    Pol II-mediated transcription and chromatin looping of CDKN1A are repressed by MAF1 through the regulation of Pol III activity.