88 results found
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity

    Wenlei Ye et al.
    TMEM16F shifts its ion selectivity in response to change of intracellular Ca2+, membrane potential and ionic strength.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity

    Jason Tien et al.
    The identification of four acidic amino acids as potential calcium-binding residues in the TMEM16A calcium-activated chloride channel furthers the molecular understanding of this ion channel family.
    1. Structural Biology and Molecular Biophysics

    Subdued, a TMEM16 family Ca2+-activated Cl channel in Drosophila melanogaster with an unexpected role in host defense

    Xiu Ming Wong et al.
    A newly characterized calcium-activated chloride channel has been implicated in the immune system of Drosophila, shedding light on an enigmatic family of transmembrane proteins that are ubiquitous in nature.
    1. Structural Biology and Molecular Biophysics

    Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A

    Andy KM Lam, Raimund Dutzler
    Ion conduction in the calcium-activated chloride channel TMEM16A is directly regulated by calcium, which binds to a site close to the pore thereby shaping the electrostatics at its intracellular entrance.
    1. Structural Biology and Molecular Biophysics

    Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins

    Angela Ballesteros et al.
    The structural relationship between TMC and TMEM16 proteins provides insight into the structure and functional mechanisms of the mechanotransduction channel complex in hair cells.
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels

    Swetha E Murthy et al.
    A family of proteins (OSCA/TMEM63) that encode mechanosensitive ion channels has been characterized in plants, flies, and mammals.
    1. Structural Biology and Molecular Biophysics

    Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A

    Cristina Paulino et al.
    Single-particle cryo-EM and electrophysiology studies of the chloride channel TMEM16A reveals the structural basis for anion conduction and uncover its relationship to lipid scramblases of the same family.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels

    Florian Ullrich et al.
    TMEM206 proteins are identified as constituting the pore of the widely expressed acid-activated chloride channel PAORAC/ASOR, which is important in acid toxicity.
    1. Neuroscience

    TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala

    Ke-Xin Li et al.
    SOM+ GABAergic neuronal signaling and inhibitory transmission in the central lateral amygdala is regulated by TMEM16B, which is also involved in fear and anxiety-like behaviors.
    1. Structural Biology and Molecular Biophysics

    Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase

    Maria E Falzone et al.
    Structures of a TMEM16 phospholipid scramblase reveal that its Ca2+-dependent activation entails global conformational changes and how these rearrangements affect the membrane to enable transbilayer lipid transfer.

Refine your results by:

Type
Research categories