159 results found
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Filopodia powered by class x myosin promote fusion of mammalian myoblasts

    David W Hammers et al.
    Filopodia driven by class X myosin promote the fusion of mammalian myoblasts in the development of skeletal muscle and are important for the regeneration of skeletal muscle following muscle injury.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Local adaptation and archaic introgression shape global diversity at human structural variant loci

    Stephanie M Yan et al.
    Graph genotyping of structural variation in diverse human populations reveals functional associations and signatures of local adaptation within poorly resolved regions of the genome.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

    Yao Rong et al.
    Electrophysiological and structural characterizations reveal that a previously proposed ion channel responsible for sensing mechanical pain is insensitive to poking or stretching stimuli for conducting ions and may serve as a coenzyme A-binding protein instead.
    1. Neuroscience

    Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair

    Oshri Avraham et al.
    The microenvironment surrounding sensory neurons in dorsal root ganglia responds differently to peripheral and central injuries, revealing that non-neuronal cells can be manipulated to promote axon regeneration after central injury.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Membrane Proteins: Pain or gain?

    Valeria Kalienkova
    The 3D structures of a membrane protein called TMEM120A suggest that it may act as an enzyme in fat metabolism rather than as an ion channel that senses mechanical pain.
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    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Enhanced Cas12a multi-gene regulation using a CRISPR array separator

    Jens P Magnusson et al.
    Cas12a CRISPR arrays are sensitive to the GC content of their spacers, but AT-rich separator sequences successfully remove this disruptive effect and enable enhanced multiplexed gene targeting and activation.
    1. Immunology and Inflammation
    2. Neuroscience

    Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

    Lindsay A Hohsfield et al.
    In an empty microglial niche, repopulating microglia arise from subventricular zone and white matter-associated areas without contributions from the bone marrow to fill the mouse brain via a spreading wave.
    1. Structural Biology and Molecular Biophysics

    TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase

    Jing Xue et al.
    Cryo-EM structure of human TMEM120A reveals that it is a coenzyme A-binding protein and is unlikely to function as a mechanosensitive channel as was recently proposed.
    1. Structural Biology and Molecular Biophysics

    Analysis of the mechanosensor channel functionality of TACAN

    Yiming Niu et al.
    Electrophysiological and structural data do not support a mechanosensitive channel function for TACAN.
    1. Cell Biology
    2. Computational and Systems Biology

    Highly localized intracellular Ca2+ signals promote optimal salivary gland fluid secretion

    Takahiro Takano et al.
    Measurement of physiological intracellular Ca2+ signals following neural stimulation in vivo reveals distinct spatiotemporal characteristics that promote optimal salivary gland fluid secretion.

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