155 results found
    1. Genetics and Genomics

    3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity

    Khanh B Trang, Matthew C Pahl ... Struan FA Grant
    Integration of GWAS summary statistics with extensive 3D genomic datasets generated in a myriad of different cell types provides genomic insights into pediatric obesity pathogenesis.
    1. Developmental Biology
    2. Genetics and Genomics

    Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition

    Anne-Sophie Pepin, Patrycja A Jazwiec ... Sarah Kimmins
    Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.
    1. Neuroscience

    Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

    Arnaud PJ Giese, Wei-Hsiang Weng ... Zubair M Ahmed
    Complexes formed by calcium- and integrin-binding proteins 2 and 3 and transmembrane channel-like proteins 1 and 2 are essential for vertebrate hearing and balance and for fish lateral line function.
    1. Cancer Biology
    2. Cell Biology

    Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

    Zijing Wang, Bihan Xia ... Jilin Yang
    The inhibition of colorectal cancer (CRC) proliferation, migration, and invasion is attributed to BEST4, which exhibits epistasis over Hes4 in the downregulation of Twist1 and consequent suppression of epithelial-to-mesenchymal transition in CRC.
    1. Neuroscience

    Single-cell transcriptomics of vomeronasal neuroepithelium reveals a differential endoplasmic reticulum environment amongst neuronal subtypes

    GVS Devakinandan, Mark Terasaki, Adish Dani
    Developmental specialization of vomeronasal sensory neurons involves selective upregulation of endoplasmic reticulum genes in a subset of neurons along with a hypertrophic gyroid membrane architecture.
    1. Developmental Biology

    Molecular, cellular, and developmental organization of the mouse vomeronasal organ at single cell resolution

    Max Henry Hills, Limei Ma ... C Ron Yu
    A transcriptomic atlas of the mouse vomeronasal organ reveals novel receptor co-expression patterns and provides a framework for understanding sensory neuron lineage and receptor specification.
    1. Immunology and Inflammation

    SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire

    Somen K Mistri, Brianna M Hilton ... Jonathan E Boyson
    The SLAM/SAP signaling pathway regulates both γδ T cell developmental programming and γδ/αβ T cell lineage commitment.

Refine your results by:

Type
Research categories