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Proteins in the Transmembrane Channel-Scramblase (TCS) superfamily share an evolutionarily conserved ability to permeate ions and phospholipids, challenging distinctions between ion channels and lipid scramblases.

The common human HAQ,AQ alleles suppress STING1 gain-of-function mutation-induced chronic STING1 inflammation in mice.

In a mouse model of Sjogren's disease, mitochondrial function and Ca²⁺ signaling are disrupted resulting in altered coupling between Ca²⁺ release and Ca²⁺ activated Cl^- channels and salivary gland hypofunction.

Novel genetic fate-mapping strategies enabled re-analysis of cortical oligodendrocytes derived from dorsal pallium, LGE/CGE, and MGE/POA, challenging the canonical view of substantial LGE/CGE contributions and the elimination of MGE/POA-derived populations.

Using a combination of all-atom molecular simulation and continuum membrane mechanics, M2 channels from influenza are shown to be stabilized in negative Gaussian curvature regions, such as the neck of budding viral particles, only in C2-symmetric conformations.

ImmCellTyper enhances CyTOF data analysis by combining expert biological knowledge with advanced clustering tools to provide an accurate, comprehensive, and user-friendly solution for high-dimensional immune profiling.