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Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.

Myomaker is activated on muscle stem cells to promote their fusion with myofibers, which is essential for induction of pro-growth signaling pathways and physiological muscle hypertrophy.

Graph genotyping of structural variation in diverse human populations reveals functional associations and signatures of local adaptation within poorly resolved regions of the genome.

Giant neuron derived vesicles called exophers are processed by phagocytosis in neighboring skin cells, and the phagocytic interaction promotes exopher production.

Older individuals have impaired conventional dendritic cell and T follicular helper cell formation upon vaccination, which can be rescued by treatment with a TLR7 agonist.

Molecular and genetics approaches reveal a dual regulatory role of neuronal G-protein-coupled receptor NPR-15 in both immunity and avoidance behavior, independent of aerotaxis, mediated by amphid sensory neurons, ASJ.

Loss of the RNA-binding protein TDP-43 impairs the survival of oligodendrocyte progenitors and reactivates growth of mature oligodendrocytes, resulting in inappropriate wrapping of neuronal somata and blood vessels.

Neutrophils are essential for itch in a mouse model of atopic dermatitis, and promote the transition from acute to chronic itch via induction of CXCL10/CXCR3 signaling.

The fertilizing potential of sperm correlates with their ability to induce viral-like fusion of somatic cells expressing JUNO.

Outward calcium ion currents desensitize the human PKD2-L1 ion channel via a mechanism that is independent of cytosolic motifs.