2,388 results found
    1. Neuroscience

    Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila

    Shun-Fan Wu et al.
    Drosophila use distinct sensory mechanisms to detect and integrate the same tactile and taste information in two decision-making tasks that serve two different purposes.
    1. Biochemistry and Chemical Biology

    Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease

    Silvia C Bobeica et al.
    Structural and biochemical characterization of the protease domain of an ABC transporter demonstrates the basis for recognition of substrate leader peptides.
    1. Neuroscience

    Transcranial magnetic stimulation (TMS) inhibits cortical dendrites

    Sean C Murphy et al.
    Studying the activity of cortical neurons in rats reveals the subcellular effects of transcranial magnetic stimulation, which is used for the non-invasive treatment of a variety of brain disorders.
    1. Neuroscience

    Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons

    Rachel S Lee et al.
    Despite the fundamental relationship between movement and value, they are represented in a separable manner in dopamine neurons.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Recombinational branch migration by the RadA/Sms paralog of RecA in Escherichia coli

    Deani L Cooper, Susan T Lovett
    The role of the bacterial protein RadA in homologous recombination – a DNA repair pathway vital to all cells – is defined.
    1. Neuroscience

    The cortical connectivity of the periaqueductal gray and the conditioned response to the threat of breathlessness

    Olivia K Faull, Kyle TS Pattinson
    Building on previous work (Faull et al, 2016), it shown that the different connectivity profiles of the individual columns of the human periaqueductal gray support their proposed roles in human threat behaviours, such as freezing or fight/flight.
    1. Structural Biology and Molecular Biophysics

    HDX-MS reveals nucleotide-dependent, anti-correlated opening and closure of SecA and SecY channels of the bacterial translocon

    Zainab Ahdash et al.
    Hydrogen-deuterium exchange mass spectrometry reveals nucleotide-driven conformational regulation of Sec protein-channel to help impose directionality for protein transport through the Sec complex.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Operon mRNAs are organized into ORF-centric structures that predict translation efficiency

    David H Burkhardt et al.
    Operonic mRNAs in bacteria are comprised of ORF (open reading frame)-wide units of secondary structure, which are intrinsically distinct between adjacent ORFs and encode a rough blueprint for ORF-specific translation efficiency.
    1. Neuroscience

    A hierarchy of timescales explains distinct effects of local inhibition of primary visual cortex and frontal eye fields

    Luca Cocchi et al.
    The selective effect of local inhibition on diffuse patterns of brain connectivity can be accounted for by an intrinsic hierarchical ordering of cortical timescales.
    1. Neuroscience

    Causal manipulation of functional connectivity in a specific neural pathway during behaviour and at rest

    Vanessa M Johnen et al.
    Functional connectivity in the human brain reflects changes in synaptic plasticity induced with repeated paired stimulation.

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