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    1. Neuroscience

    Causal manipulation of functional connectivity in a specific neural pathway during behaviour and at rest

    Vanessa M Johnen et al.
    Functional connectivity in the human brain reflects changes in synaptic plasticity induced with repeated paired stimulation.
    1. Neuroscience

    Cortical excitability controls the strength of mental imagery

    Rebecca Keogh et al.
    Visual and prefrontal cortex excitability predict individual differences in visual imagery strength, and modulating excitability in these cortical regions causally alters the strength of visual imagery.
    1. Neuroscience

    Fatigue induces long-lasting detrimental changes in motor-skill learning

    Meret Branscheidt et al.
    A series of experiments shows how muscle fatigue impairs motor-skill learning on subsequent practice days beyond its effects on task execution.
    1. Computational and Systems Biology

    Metabolic network percolation quantifies biosynthetic capabilities across the human oral microbiome

    David B Bernstein et al.
    A novel metabolic network analysis method enables large-scale computational predictions of biosynthetic capabilities across the human oral microbiome, revealing a unique cluster of fastidious microorganisms and potential metabolic interdependencies.
    1. Neuroscience

    HCN2 channels in the ventral tegmental area regulate behavioral responses to chronic stress

    Peng Zhong et al.
    HCN2 channels in the ventral tegmental area play an important role in the pathophysiology of chronic mild stress-induced behavioral deficits.
    1. Neuroscience

    Lifting the veil on the dynamics of neuronal activities evoked by transcranial magnetic stimulation

    Bingshuo Li et al.
    A cellular-level in vivo investigative method that provides unprecedented insights into the dynamics of neuronal activities evoked by transcranial magnetic stimulation.
    1. Neuroscience

    The causal role of the somatosensory cortex in prosocial behaviour

    Selene Gallo et al.
    A combination of human imaging and brain stimulation techniques show that the somatosensory cortex is essential to prosocial decision making, by transforming observed pain in accurate perception of others' distress.
    1. Biochemistry and Chemical Biology

    Efficient analysis of mammalian polysomes in cells and tissues using Ribo Mega-SEC

    Harunori Yoshikawa et al.
    Translationally active polysomes from mammalian cells/tissues are successfully separated with rapidity, high efficiency and exceptional reproducibility by a SEC-based approach, an accessible alternative to the conventional sucrose density gradient analysis.
    1. Physics of Living Systems

    High-speed motility originates from cooperatively pushing and pulling flagella bundles in bilophotrichous bacteria

    Klaas Bente et al.
    Bacteria reach swimming speeds of several hundred body lengths per second and change direction in less than 5 ms by using coordinated flagella bundle agitation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS

    Tony Ly et al.
    A detailed analysis of protein abundance and phosphorylation changes across mitotic subphases and interphase in asynchronously growing human cells has been enabled by combining FACS with quantitative MS-based proteomics.