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    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations

    Jing Xue et al.
    Cryo-EM analysis of human ZnT8 reveals a large conformational change of TMD during the transport cycle.
    1. Structural Biology and Molecular Biophysics

    Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins

    Angela Ballesteros et al.
    The structural relationship between TMC and TMEM16 proteins provides insight into the structure and functional mechanisms of the mechanotransduction channel complex in hair cells.
    1. Computational and Systems Biology

    Selecting the most appropriate time points to profile in high-throughput studies

    Michael Kleyman et al.
    The Time Point Selection (or TPS) method is a general protocol for determining sampling rates for high throughout time series biological studies, that is efficient, cheap, scalable and works well for several different types of molecular data.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome

    Emma A Morrison et al.
    The BPTF PHD finger is inhibited from binding the methylated H3 tails in the context of the nucleosome due to their robust interaction with the nucleosomal DNA, which can be modulated by additional histone PTMs.
    1. Neuroscience

    Synergistic actions of v-SNARE transmembrane domains and membrane-curvature modifying lipids in neurotransmitter release

    Madhurima Dhara et al.
    Naturally-occurring v-SNARE TMD variants differentially regulate fusion pore dynamics and cooperate with phospholipids in supporting membrane curvature at the fusion pore neck.
    1. Plant Biology

    Correction: A tension-adhesion feedback loop in plant epidermis

    Stéphane Verger et al.
    1. Neuroscience

    Neuromodulation: Transcranial electric stimulation seen from within the brain

    Angel V Peterchev
    Computer models can make transcranial electric stimulation a better tool for research and therapy.
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    1. Stem Cells and Regenerative Medicine

    Cutting Edge: Promoting international collaboration and creativity in doctoral students

    Christopher M Groen et al.
    Staff from the Mayo Clinic in the US and the Karolinska Institute in Sweden describe a joint transatlantic course intended to broaden the horizons of the next generation of researchers in the field of regenerative medicine.