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Real-time visualization of Salmonella enterica and polarized macrophage interaction in the living host identifies an anti-inflammatory, pro-regenerative, and motionless macrophage subset as a survival niche during persistent infection.

Cancer-directed treatment using Tumor-Treating Fields spatially modulates the tumor microenvironment at the cellular and molecular levels, decreasing nanotube-based cellular networks of communication while creating a microenvironment more susceptible to immunotherapeutic strategies.

TNFAIP2 was found to interact with IQGAP1 and Integrin β4, which activates RAC1 through TNFAIP2 and IQGAP1 and confers DNA damage-related drug resistance in triple-negative breast cancer.

An extensive characterization of inflammatory cell dynamics, function, and potential interaction during zebrafish cardiac repair identified specific resident macrophage subsets function in debris clearance, inflammatory resolution, and extracellular matrix remodeling, indispensable for successful heart regeneration.

Continuing advances in functional genomics will enable systematic characterization of how non-coding genetic variation at enhancers impacts developmental diseases.

Enhanced proteasomal degradation of TNFAIP3 proteins carrying missense variations is one of the pathophysiological mechanisms underlying HA20.

The levels of the cytokine BAFF increase across senescence paradigms, in turn triggering a secretory phenotype in some senescent cells and activating p53 in other senescent cells.

Age-related tendon degeneration is initiated by loss of tenocytes associated with synthesis of high-turnover rate proteoglycans and glycoproteins.