4,600 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit

    Hisashi Tatebe et al.
    Sin1, a regulatory subunit of TOR protein kinase, has an evolutionarily conserved domain that specifically binds and recruits substrate for phosphorylation, and may represent a potential target for anti-cancer drugs.
    1. Cell Biology

    Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases

    Kim Hou Chia et al.
    The Rag-family GTPases, known activators of TOR complex 1 (TORC1), also function as attenuator that prevents deregulated hyperactivation of TORC1 signaling.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence

    Christina FS Mages et al.
    Lin37 is essential for cell-cycle gene repression by the DREAM complex in cellular quiescence and a combined loss of Lin37 and Rb prevents cell-cycle exit in response to growth-limiting signals.
    1. Cell Biology

    Two distinct mechanisms target the autophagy-related E3 complex to the pre-autophagosomal structure

    Kumi Harada et al.
    How the autophagy-related E3 complex localizes to pre-autophagosomal structures and a non-E3 function of the complex were revealed, significantly advancing our understanding of the nucleation step in autophagosome formation.
    1. Cell Biology

    The yeast H+-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H+-coupled nutrient uptake

    Elie Saliba et al.
    The H+ influx coupled to nutrient uptake and the plasma membrane H+-ATPase are central actors of the activation of target of rapamycin complex 1 (TORC1) in budding yeast Saccharomyces cerevisiae..
    1. Cell Biology

    MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture

    Jonathan R Friedman et al.
    A conserved mitochondrial inner membrane complex called MICOS works together with the mitochondrial lipid cardiolipin and respiratory complexes to direct the position, copy number and stabilization of cristae structures for efficient respiration.
    1. Biochemistry and Chemical Biology

    Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex

    Mingxuan Wu et al.
    Biochemical approaches reveal that an epigenetic histone deacetylase complex called CoREST is slow to deacetylate histone H3 lysine-14 in nucleosomes, and this inhibits demethylation of histone H3 lysine-4 by the CoREST complex.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation

    Martijn S Luijsterburg et al.
    A new mechanism is uncovered by which the RNF168 ubiquitin ligase couples PALB2-dependent homologous recombination to H2A ubiquitylation to promote DNA repair and preserve genome integrity.
    1. Chromosomes and Gene Expression

    RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes

    Nathan R Rose et al.
    The E3 ubiquitin ligase activity of polycomb repressive complex 1 is stimulated by RYBP to support a histone modification-dependent communication between polycomb repressive complexes in mice.

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