A set of ex vivo and in vivo experiments, including genetic ablation and regeneration studies, identify a key regulatory function of SOXF factors in muscle stem cells in mice.
Donato Giovannelli, Stefan M Sievert ... Costantino Vetriani
The genome of Thermovibrio ammonificans encodes ancestral pathways (e.g., hydrogen oxidation) and more recently acquired ones (e.g., nitrate reduction) and a hybrid pathway for CO2 fixation.
A gain-of-function in a new chemical defense resulted in no trade-offs and and independent evolution between novel and ancestral defenses, suggesting low redundancy among different defensive chemicals.
Hungry flies shifting from cooler to warmer temperature preferences in response to non-nutritive food indicates a taste-triggered response, similar to the cephalic phase response observed in mammals.
Jonathon Alexis Coates, Elliot Brooks ... Iwan Robert Evans
Drosophila macrophages are a heterogeneous population of cells containing subpopulations with enhanced responses to injury that display considerable variation in their abundance across development.
Gut microbiota can influence mPFC transcriptional profiles and myelin content, overriding the impact of genetic background in the development of social avoidance behavior.
A novel multi-omics framework revealed the taxonomic contribution to microbiota oxalate, demontrated O. formigenes as the dominating taxon transcriptionally, and identified specific IBD cohort at risk for oxalte toxicity.