Viral evolution can lead to mutations that render specific glycosylation sites dispensable for folding and for supporting the protein's function, allowing changes in the shield, and in the immunogenic profile.
Zachary Paul Billman, Stephen Bela Kovacs ... Edward A Miao
Amphibians, reptiles, and birds engage pyroptosis using caspase-1 and GSDMA, filling an evolutionary gap in which caspase-1 cleaves GSDME in fish and GSDMD in mammals.
Jakub Witold Bubnicki, Marcin Churski ... Dries PJ Kuijper
The spatial interactions between humans, large carnivores and herbivores cascade down in a complex but predictable way to lower trophic levels affecting regeneration of tree species in a temperate forest.
The utility of an in vitro cell culture system for studies of molecular mechanisms underlying the initial induction and subsequent propagation of environmentally induced epimutations is demonstrated.
Jennifer McKey, Dilara N Anbarci ... Blanche Capel
A detailed characterization of mouse ovary development using tissue clearing and 3D lightsheet imaging identifies ovary folding, specification of cortical and medullary domains, and ovary encapsulation as major hallmarks of ovary morphogenesis.
Evelyn Jagoda, Davide Marnetto ... Terence D Capellini
Key functional variants, discovered using Massively Parallel Reporter Assay (MPRA) and reporter assays in the context of SARS-CoV-2 infection, support the importance of two critical chemokine receptor genes CCR1 and CCR5 in severe Covid-19 illness.
Leveraging the US Health and Retirement Study and C. elegans genetics reveals ALDH4A1/alh-6 as an evolutionarily conserved biomarker for normal muscle function over the lifespan.
There was substantial change in primary care activity following the onset of the COVID-19 pandemic in March 2019 as indicated by key measures reflective of clinical activity in general practice but service was largely restored by April 2021.
Marina A Kasimova, Debanjan Tewari ... Baron Chanda
The gating polarity of a voltage-gated ion channel is primarily determined by turn propensity of residues at a critical position in the middle of the S4 voltage-sensing helix.
