Browse the search results

Soluble fragments cleaved from the N-terminus of PC-1 activate the PC-1/PC-2 heteromeric polycystin channel, describing for the first time that the N-terminus itself is an endogenous ligand.

Polymorphic residues of a vacuolar Ca²⁺ sensor site in TPC1 channels differ between species of Brassicacea and Fabaceae and lead to distinct TPC1 gating behavior.

Drosophila use distinct sensory mechanisms to detect and integrate the same tactile and taste information in two decision-making tasks that serve two different purposes.

Evidence is provided suggesting that heterochromatin re-organisation during cell senescence can compromise the structural integrity of the nucleus, leading to activation of an inflammatory process.

Sterol kinetics and cell-based assays reveal a heretofore unknown step in cholesterol trafficking through the endolysosomal compartment, involving a direct functional interaction between NPC2 and lysosbisphosphatidic acid.

Ezrin controls endo-lysosomal signaling by maintaining TSC inhibition through EGFR signaling, activating mTORC1, and inhibiting lysosomal function, unveiling a critical endosome–lysosome network essential for autophagy and cellular homeostasis.

Exposing chicks to one hour of light during the night disrupts the releaseof a hormone that is needed by cells in the developing brain to survive.

G9a regulates chromatin-bound b-catenin enabling cell-intrinsic control of WNT signaling-mediated cell fate decisions.

A new dynamic mechanistic model explains how the destruction complex negatively regulates Wnt signaling in development and oncogenesis.

A chromatin remodeling factor cooperates with Wnt signaling pathway to transcribe erythropoietin in the adult liver, inducing its secretion and a dramatic erythropoiesis in the spleen.