8,181 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Basalin is an evolutionarily unconstrained protein revealed via a conserved role in flagellum basal plate function

    Samuel Dean et al.
    Basalins are intrinsically disordered proteins with astonishingly high-sequence divergence that are essential for building the transition zone basal plate and for proper central pair nucleation.
    1. Neuroscience

    Extracting grid cell characteristics from place cell inputs using non-negative principal component analysis

    Yedidyah Dordek et al.
    Computational modeling of the brain’s navigation system reveals that place cells can drive the formation of hexagonal patterns experimentally observed in grid cells activity.
    1. Developmental Biology
    2. Evolutionary Biology

    Secondary ossification center induces and protects growth plate structure

    Meng Xie et al.
    The principle underlying the appearance of the growth plate, an organ responsible for longitudinal growth, has implications for various cartilage pathologies including growth abnormalities in children, trauma and osteoarthritis.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The universally-conserved transcription factor RfaH is recruited to a hairpin structure of the non-template DNA strand

    Philipp K Zuber et al.
    Transcription factors can read out both the sequence and the structure of the non-template DNA strand in the transcription bubble, expanding the repertoire of mechanisms to control transcription.
    1. Structural Biology and Molecular Biophysics

    Using the Volta phase plate with defocus for cryo-EM single particle analysis

    Radostin Danev et al.
    Building on previous work in cryo-electron microscopy (Entchev et al, 2015), it shown that a combination of the Volta phase plate and a small amount of defocus can simplify the experimental set-up, increase the data acquisition rate and improve resolution.
    1. Neuroscience

    Hippocampal place cells construct reward related sequences through unexplored space

    H Freyja Ólafsdóttir et al.
    In anticipation of a reward, hippocampal place cells simulate desired journeys through areas that have been seen, but not explored.
    1. Neuroscience

    Social observation enhances cross-environment activation of hippocampal place cell patterns

    Xiang Mou, Daoyun Ji
    Place cells associated with track-running are activated in rats staying in a nearby box while another rat running on the track, suggesting that social observation facilitates spatial memory representations.
    1. Neuroscience

    Place cells on a maze encode routes rather than destinations

    Roddy M Grieves et al.
    Place cells in the rat hippocampus encode positions along well-learned routes as opposed to intended destinations.
    1. Neuroscience

    Episodic-like memory trace in awake replay of hippocampal place cell activity sequences

    Susumu Takahashi
    What will happen where and when could be predicted by the sequential reactivation of place cells that occurs while an animal pauses, suggesting that the replay is linked to mental time travel.
    1. Cell Biology
    2. Neuroscience

    Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

    Marta Palomo-Guerrero et al.
    The pseudoenzyme CPT1C is able to sense changes in intracellular malonyl-CoA levels caused by nutrients or energy stress and regulate late endosomes/lysosomes anterograde transport, necessary for proper axon growth.

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