7,010 results found
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    A specific E3 ligase/deubiquitinase pair modulates TBP protein levels during muscle differentiation

    Li Li et al.
    Proteasome-mediated degradation of the TATA-box binding protein (TBP) during terminal differentiation is regulated by the E3 ligase Huwe1 and the deubiquitinase USP10.
    1. Cell Biology
    2. Neuroscience

    TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells

    Kae-Jiun Chang et al.
    Glial TDP-43 regulates splicing and expression of neurofascin and is required for proper assembly and maintenance of paranodal axoglial junctions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Architecture of TAF11/TAF13/TBP complex suggests novel regulation properties of general transcription factor TFIID

    Kapil Gupta et al.
    Integrative structural biology reveals a novel complex comprising the TATA-box-binding protein, TBP, and two subunits, TAF11 and TAF13, of General Transcription Factor TFIID, suggesting a new regulatory state in TFIID function in RNA polymerase II transcription initiation.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    TBP/TFIID-dependent activation of MyoD target genes in skeletal muscle cells

    Barbora Malecova et al.
    Genetic and biochemical evidence shows that the basal transcription machinery of muscle cells invariably relies on TBP/TFIID because TBP2 is not expressed in muscle cells, and thus resolves a longstanding issue raised by previous conflicting data.
    1. Neuroscience

    Dissociable laminar profiles of concurrent bottom-up and top-down modulation in the human visual cortex

    Samuel JD Lawrence et al.
    Neural activity in the visual system is increased in different layers of the neocortex for bottom-up and top-down modulations.
    1. Cell Biology
    2. Developmental Biology

    Dpp from the anterior stripe of cells is crucial for the growth of the Drosophila wing disc

    Shinya Matsuda, Markus Affolter
    A recent report proposing that the dpp stripe (the main source of the protein dpp) is dispensable for Drosophila wing disc growth missed the critical role on growth due to imprecise spatial removal of dpp.
    1. Neuroscience

    APP modulates KCC2 expression and function in hippocampal GABAergic inhibition

    Ming Chen et al.
    APP interacts with KCC2 to limit the latter from tyrosine-phosphorylation and ubiquitination and thus subsequent degradation, revealing a novel molecular pathway in which APP regulates GABAergic signaling and thus inhibition in the hippocampus.
    1. Developmental Biology

    Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis

    Benoit Vanhollebeke et al.
    The membrane proteins Reck and Gpr124 are integral components of a novel Wnt7a/Wnt7b-specific signaling complex, and there is a distinctive requirement for Wnt/β-catenin signaling in tip cells during angiogenesis in the central nervous system.
    1. Neuroscience

    Bottom-up and top-down influences at untrained conditions determine perceptual learning specificity and transfer

    Ying-Zi Xiong et al.
    Perceptual learning is specific because of the absence of bottom-up stimulation and top-down modulation at the untrained conditions.
    1. Structural Biology and Molecular Biophysics

    Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1

    Agata Butryn et al.
    A structural analysis of the transcription regulator Mot1 in complex with promoter DNA and the proteins TBP and NC2 provides a first structural framework for how a Swi2/Snf2 type remodeler interacts with a histone fold protein:DNA complex.

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