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    1. Epidemiology and Global Health

    Adiposity may confound the association between vitamin D and disease risk – a lifecourse Mendelian randomization study

    Tom G Richardson, Grace M Power, George Davey Smith
    Genetic analyses provide evidence that adiposity influences vitamin D levels at different timepoints over the lifecourse, suggesting that associations previously reported between vitamin D deficiency and disease by conventional epidemiological studies may have been prone to confounding.
    1. Chromosomes and Gene Expression

    miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila

    Manish Pandey, Sakshi Bansal ... Geetanjali Chawla
    miR-125 functions as a potential dietary restriction mimetic by promoting longevity through regulation of fat metabolism.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    CaMKII autophosphorylation can occur between holoenzymes without subunit exchange

    Iva Lučić, Léonie Héluin ... Andrew JR Plested
    CaMKII is capable of spreading activity between holoenzymes without exchanging subunits.
    1. Cell Biology
    2. Computational and Systems Biology

    Microtubule reorganization during female meiosis in C. elegans

    Ina Lantzsch, Che-Hang Yu ... Stefanie Redemann
    Structural rearrangements of meiotic spindles during the transition from metaphase to anaphase can be controlled by local changes of microtubule dynamics, such as nucleation and/or turnover, and that katanin promotes microtubule turnover by severing microtubules near the chromosomes.
    1. Biochemistry and Chemical Biology

    High-throughput proteomics of nanogram-scale samples with Zeno SWATH MS

    Ziyue Wang, Michael Mülleder ... Markus Ralser
    Zeno SWATH MS, a novel data-independent acquisition technique in proteomics, which by facilitating sensitive detection in high-throughput experiments with low sample amounts, mitigates current bottlenecks of high-throughput proteomics.
    1. Neuroscience

    Navigating the garden of forking paths for data exclusions in fear conditioning research

    Tina B Lonsdorf, Maren Klingelhöfer-Jens ... Christian J Merz
    Exclusion of participants in tasks with a learning element can introduce substantial bias and needs to be carefully considered and transparently reported and justified.
    1. Plant Biology

    Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet

    Carla de la Fuente, Alexandre Grondin ... Laurent Laplaze
    Increased primary root growth in pearl millet is correlated with early water stress tolerance, an important constraint in agrosystems in the Sahel, and is associated with the regulation of root cell elongation by a glutaredoxin.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Bacterial flagella grow through an injection-diffusion mechanism

    Thibaud T Renault, Anthony O Abraham ... Marc Erhardt
    Single cell, fluorescent microscopy and mathematical modeling reveal how bacterial flagella dynamically assemble outside the cell.
    1. Neuroscience

    Dopamine enhances model-free credit assignment through boosting of retrospective model-based inference

    Lorenz Deserno, Rani Moran ... Raymond J Dolan
    Cooperation between model-free and model-based control systems is boosted by enhancing dopamine levels.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A variant-centric perspective on geographic patterns of human allele frequency variation

    Arjun Biddanda, Daniel P Rice, John Novembre
    New tools for visualizing population genetic data can provide a more direct understanding of levels of differentiation among human populations.