4,835 results found
    1. Chromosomes and Gene Expression

    The molecular basis of coupling between poly(A)-tail length and translational efficiency

    Kehui Xiang, David P Bartel
    For poly(A)-tail length to influence mRNA translational efficiency, poly(A)-binding protein (PABPC) must be limiting, mRNAs lacking PABPC must be stable, and translation initiation must be sensitive to PABPC levels.
    1. Cancer Biology
    2. Physics of Living Systems

    Oxaliplatin resistance in colorectal cancer enhances TRAIL sensitivity via death receptor 4 upregulation and lipid raft localization

    Joshua D Greenlee et al.
    Oxaliplatin-resistant colorectal cancer cells exhibit unregulated death receptor 4 expression with increased receptor palmitoylation and translocation into lipid rafts, increasing their sensitivity to apoptosis via TRAIL.
    1. Ecology
    2. Evolutionary Biology

    Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications

    Susanne RK Zajitschek et al.
    Sex differences in trait variability imply that both sexes should be included in biomedical trials, using sex-specific statistical power calculations.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Concerted regulation of ISWI by an autoinhibitory domain and the H4 N-terminal tail

    Johanna Ludwigsen et al.
    The N-terminal domain of the chromatin remodeler ISWI contains previously uncharacterized conserved motifs that maintain structure, prevent ATP hydrolysis unless nucleosomes are bound, and confer H4-tail sensitivity without directly competing with the H4 tail.
    1. Ecology
    2. Computational and Systems Biology

    A locally-blazed ant trail achieves efficient collective navigation despite limited information

    Ehud Fonio et al.
    Ants employ a new kind of trail to resolve group-level navigational difficulties in scenarios where the information available to individuals does not suffice.
    1. Cancer Biology

    Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

    Krishna Kalyan Kolluri et al.
    Loss of BAP1 function is associated with increased sensitivity to TRAIL and other death receptor agonists in malignant mesothelioma, where this is a frequent event, with immediate and actionable therapeutic implications.
    1. Neuroscience

    Leave-One-Trial-Out, LOTO, a general approach to link single-trial parameters of cognitive models to neural data

    Sebastian Gluth, Nachshon Meiran
    Leave-One-Trial-Out (LOTO) is a general, efficient and easily implementable approach for inferring trial-by-trial measures of computational model parameters in order to link these measures to neural mechanisms.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

    Tatyana Bodrug et al.
    Biochemical, single molecule, cell and structural biology studies reveal an interaction between the kinesin-5 tail and motor domains regulating high-force production, which is critical for microtubule sliding motility.
    1. Neuroscience

    Shared neural underpinnings of multisensory integration and trial-by-trial perceptual recalibration in humans

    Hame Park, Christoph Kayser
    Facing discrepancies in the sensory environment, multisensory information is combined in the medial superior parietal cortex to guide immediate judgements and to also adjust subsequent unisensory perception.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    mRNA poly(A)-tail changes specified by deadenylation broadly reshape translation in Drosophila oocytes and early embryos

    Stephen W Eichhorn et al.
    Profiling of mRNA poly(A)-tail lengths and translational efficiencies provides new insights into posttranscriptional gene regulation in early Drosophila development.

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