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    1. Structural Biology and Molecular Biophysics

    Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies

    Haoqing Wang et al.
    Single particle cryoEM structure of antibody complex with HIV-1 envelope trimer reveals new mode of asymmetric recognition of trimer apex.
    1. Structural Biology and Molecular Biophysics

    Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates

    Iordan Iordanov et al.
    Invertebrate TRPM2 channels have stable pores but act as chanzymes that hydrolyze their activating ligand ADP ribose (ADPR), whereas vertebrate TRPM2 channels are catalytically dead but undergo pore inactivation.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

    Xiaochu Ma et al.
    The identification of a single-CD4 bound asymmetric HIV-1 Envelope trimer intermediate provides new mechanistic insights into the activation of Envelope for fusion, and highlights the importance of asymmetry in biology.
    1. Structural Biology and Molecular Biophysics

    Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

    Andrew J Borst et al.
    An integrative structural and biophysical workflow indicates engagement of VRC01 germline antibodies can occur with a gp120 426c core construct containing all wild-type N-linked glycosylation sites, including the Asn276 glycan.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

    Iordan Iordanov et al.
    TRPM2 is simply a ligand gated channel and does not to possess enzymatic activity, even though it shows sequence similarity to Nudix hydrolases.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein

    Rupa Banerjee et al.
    Two domains of the peripheral membrane protein Tim44 interact with two different sectors of a translocase to coordinate the translocation of proteins across the inner mitochondrial membrane.
    1. Neuroscience

    Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau

    Maxime WC Rousseaux et al.
    Loss of a developmentally essential gene in adulthood is tolerated in mice, thus offering potential therapeutic options for Alzheimer's and Parkinson's disease.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Dual interaction of scaffold protein Tim44 of mitochondrial import motor with channel-forming translocase subunit Tim23

    See-Yeun Ting et al.
    The motor that drives preproteins into the mitochondrial matrix is coupled to the translocase by Tim44, a two-domain scaffold protein with an intrinsically disordered "dynamic arm" and a structurally stable anchoring domain.
    1. Microbiology and Infectious Disease

    Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch

    Benjamin Rauwel et al.
    Inactivation of KAP1 by mTOR-mediated phosphorylation releases human cytomegalovirus from latency, and has the potential to be used as a therapy to purge the virus from transplant organs.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch

    Zijun Wang et al.
    Rhesus macaques can develop broadly neutralizing antibodies (bNAbs) against the V3-glycan patch of Env that resembles human V3/N332 bNABs.