469 results found
    1. Developmental Biology

    Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

    Fabienne Benz, Viraya Wichitnaowarat ... Stefan Liebner
    Endothelial tightening by augmenting low level Wnt/β-catenin activity in vessels of the mouse subfornical organ, influences neuronal activation in water-deprived mice, linking endothelial barrier properties to neuro-vascular coupling.
    1. Cell Biology

    Caveolae couple mechanical stress to integrin recycling and activation

    Fidel-Nicolás Lolo, Dácil María Pavón ... Miguel A del Pozo
    Caveolae regulate integrin mechanosensing by establishing a force threshold for activation and recycling.
    1. Cell Biology

    Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion

    Yang Zhang, Pengfei Liang ... Huanghe Yang
    A previously unknown calcium channel in human placental trophoblasts provides a calcium source for activating TMEM16F lipid scramblase that flip-flops phospholipids on cell surface, demonstrating a physiological mechanism that helps to understand how lipid dynamics regulates cell fusion.
    1. Cell Biology
    2. Neuroscience

    Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

    Rituparna Chakrabarti, Lina María Jaime Tobón ... Carolin Wichmann
    Ultrastructural analysis of optogenetically stimulated inner hair cell ribbon synapses reveals normally sized synaptic vesicles and enhanced vesicle docking at the active zone membrane.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A compartmentalized signaling network mediates crossover control in meiosis

    Liangyu Zhang, Simone Köhler ... Abby F Dernburg
    A regulatory circuit that localizes to the synaptonemal complex, a liquid crystalline compartment between chromosomes, ensures crossing-over while limiting the number of crossovers between homologous chromosomes during meiosis.
    1. Neuroscience

    Functional and microstructural plasticity following social and interoceptive mental training

    Sofie Louise Valk, Philipp Kanske ... Tania Singer
    Training attention-mindfulness, emotion-motivational, and social cognitive skills over the course of 3 months alters brain functional and microstructural organization as a function of training content.
    1. Neuroscience

    A statistical framework to assess cross-frequency coupling while accounting for confounding analysis effects

    Jessica K Nadalin, Louis-Emmanuel Martinet ... Mark A Kramer
    A new measure for cross-frequency coupling assesses phase-amplitude coupling and amplitude-amplitude coupling, and accounts for confounding factors such as low-frequency amplitude fluctuations, using a flexible statistical modeling approach.
    1. Chromosomes and Gene Expression
    2. Medicine

    Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia

    Tamara Garrido-Gomez, Nerea Castillo-Marco ... Carlos Simon
    The in vivo transcriptomic fingerprint encoding defective decidualization comprises 120 genes associated with an imbalance hormonal signaling in the decidual endometria of women who developed severe preeclampsia.
    1. Computational and Systems Biology
    2. Neuroscience

    A connectome and analysis of the adult Drosophila central brain

    Louis K Scheffer, C Shan Xu ... Stephen M Plaza
    New reconstruction methods are used to create a publicly available dense reconstruction of the neurons and chemical synapses of central brain of Drosophila, with analysis of its graph properties.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Formicine ants swallow their highly acidic poison for gut microbial selection and control

    Simon Tragust, Claudia Herrmann ... Heike Feldhaar
    Poison acidified crops sanitize food and limit disease transmission while at the same time structuring the gut microbiota and thus contribute to the ecological and evolutionary success of formicine ants.

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