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A microfluidic device induces doxorubicin-resistant polyaneuploid cancer cells from triple negative breast cancer cells, revealing NUPR1/HDAC11 axis dysfunction drives chemoresistance, increasing tumor heterogeneity and impacting clinical outcomes.

Elucidation of GLI1-Notch1 axis as key determinant of racial disparity in TNBC growth in African American and White American women.

The role of the Frazzled chemoattractant receptor is to triggers migration initiation as part of the glial developmental program induced by the Glide/Gcm transcription factor.

Identification of a pro-tumorigenic and pro-metastatic role of EHD2 protein in triple-negative breast cancer (TNBC) through the store-operated calcium entry (SOCE) pathway provides a rationale for potential targeting of EHD2-overexpressing TNBC with SOCE inhibitors.

Native mass spectrometry reveals the thermodynamic basis for high-affinity lipid binding to the ABC transporter MsbA.

Stereotactic body radiotherapy combined with immunotherapy and chemotherapy in neoadjuvant setting exhibited a promising anti-tumor activity and an acceptable safety profile in triple-negative breast cancer patients.

ctDNA predict prognosis and treatment response of mTNBC patients more sensitively than traditional tumor markers, which implies ctDNA may be valuable for individualized treatment decision-making and paves the way for a non-invasive real-time clinical management strategy in patients with mTNBC.

An integrated biochemical and evolutionary analysis shows how enzyme specificity evolves after gene loss during genome decay, implicating relaxation of purifying selection as a driving force for functional divergence.

LIPG, a lipoprotein lipase, executes its oncogenic function in human basal-like triple-negative breast cancer through its functional involvement in DTX3L-ISG15 signaling, an interferon-related pathway that regulates protein functionality by ISGylation.

Machine learning-assisted experiments reveal CD81 as a novel binding partner of CD44 in driving cancer stemness, tumor cell clustering, and extracellular vesicle integrity in human and mouse breast cancer.