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    1. Cell Biology
    2. Microbiology and Infectious Disease

    PomX, a ParA/MinD ATPase activating protein, is a triple regulator of cell division in Myxococcus xanthus

    Dominik Schumacher et al.
    In the PomX/Y/Z cell division regulatory system, PomX is a PomZ ATPase activating protein, a scaffold for PomX/Y/Z complex formation, and important for fission of the PomX/Y/Z complex during division.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Understanding patterns of HIV multi-drug resistance through models of temporal and spatial drug heterogeneity

    Alison F Feder et al.
    In triple-drug-treated HIV, partially resistant viruses can spread and resistance to specific drugs evolves in a predictable order, potentially a result of spatial or temporal heterogeneity in drug concentrations.
    1. Structural Biology and Molecular Biophysics

    A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl/H+ transport cycle

    Tanmay S Chavan et al.
    Crystallography together with electron-resonance spectroscopy, molecular-dynamics simulations, and transport measurements reveal the molecular details of protein conformational change, and how this change contributes to function in a CLC-type chloride/proton exchanger.
    1. Developmental Biology

    The Glide/Gcm fate determinant controls initiation of collective cell migration by regulating Frazzled

    Tripti Gupta et al.
    The role of the Frazzled chemoattractant receptor is to triggers migration initiation as part of the glial developmental program induced by the Glide/Gcm transcription factor.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Evolution of substrate specificity in a retained enzyme driven by gene loss

    Ana Lilia Juárez-Vázquez et al.
    An integrated biochemical and evolutionary analysis shows how enzyme specificity evolves after gene loss during genome decay, implicating relaxation of purifying selection as a driving force for functional divergence.
    1. Computational and Systems Biology
    2. Ecology

    Individual crop loads provide local control for collective food intake in ant colonies

    Efrat Esther Greenwald et al.
    Colony satiation level determines the unloading rate of laden foragers, which, in turn, rely on their own food load to adjust their foraging effort.
    1. Cell Biology
    2. Cancer Biology

    MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells

    Yubao Wang et al.
    Maternal embryonic leucine zipper kinase (MELK) is a new anti-cancer target that is highly selective for basal-like breast cancer.
    1. Developmental Biology

    Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of R-spondin1 in mouse sex reversals

    Nainoa Richardson et al.
    Sox8 can induce female-to-male sex reversal of the R-spondin1 loss-of-function mouse mutants in the absence of Sox9..
    1. Cell Biology

    Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits

    Mirko Messa et al.
    Epsin has a key role in the coupling of actin to endocytic clathrin coated pits that is required for their maturation and helps capture SNAREs at endocytic clathrin coated pits.
    1. Neuroscience

    Functional gradients of the cerebellum

    Xavier Guell et al.
    Cerebellar functional regions follow a gradual organization, which progresses from primary (motor) to transmodal (Default Mode Network) regions, and a secondary axis extends from task-unfocused to task-focused processing.