4,558 results found
    1. Structural Biology and Molecular Biophysics

    Regulatory switch at the cytoplasmic interface controls TRPV channel gating

    Lejla Zubcevic et al.
    C-terminal domain of thermoTRPV channels regulates channel gating at the cytoplasmic interface through a switch-like process.
    1. Structural Biology and Molecular Biophysics

    High temperature sensitivity is intrinsic to voltage-gated potassium channels

    Fan Yang, Jie Zheng
    Highly temperature-sensitive behavior of voltage-gated potassium channels provides a mechanistic model for how heat-activated TRP channels serve as temperature and pain sensors.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity

    Feng Zhang et al.
    TRPV channels share general mechanisms of activation while exhibiting subtype-specific features along the activation pathway that can determine their apparent sensitivity to stimuli.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the polycystin 2-l1 ion channel

    Raymond E Hulse et al.
    The selectivity characteristics of PC-2L1, which make it a principal source of calcium in primary cilia function, is presented and advances understanding of the similarity and differences of TRPP ion channels.
    1. Structural Biology and Molecular Biophysics

    Irreversible temperature gating in trpv1 sheds light on channel activation

    Ana Sánchez-Moreno et al.
    Temperature-activated TRPV1 ion channels respond to increased temperatures by opening and then entering an inactivated state from which they cannot recover, suggesting that this form of irreversible gating results from partial unfolding during heat absorption.
    1. Structural Biology and Molecular Biophysics

    Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes

    Lejla Zubcevic et al.
    Ligand-induced two-fold symmetric arrangement in TRPV2 is observed in the native-like nanodisc-reconstituted condition using cryo-electron microscopy.
    1. Structural Biology and Molecular Biophysics

    Electron cryo-microscopy structure of the canonical TRPC4 ion channel

    Deivanayagabarathy Vinayagam et al.
    Structural insights into the architecture and functional properties of zebrafish TRPC4 are revealed by high-resolution cryo-EM.
    1. Neuroscience

    Dopamine signaling tunes spatial pattern selectivity in C. elegans

    Bicheng Han et al.
    Natural variations in touch-dependent dopamine signaling tune the perception of spatial patterns in C. elegans.
    1. Neuroscience

    Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila

    Seol Hee Im et al.
    The Drosophila equivalent of Substance P signaling modulates nociceptive sensitization by regulating Hedgehog signaling within nociceptive sensory neurons.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Atypical calcium regulation of the PKD2-L1 polycystin ion channel

    Paul G DeCaen et al.
    Outward calcium ion currents desensitize the human PKD2-L1 ion channel via a mechanism that is independent of cytosolic motifs.

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