262 results found
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol

    Justyna B Startek et al.
    The activation and membrane localization of the broadly-tuned noxious chemosensory cation channel TRPA1 are regulated by direct interactions with cholesterol via CRAC motifs in transmembane segments 2 and 4.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1

    Daniel Elnatan et al.
    A flip of the dimer asymmetry following the first ATP hydrolysis provides a mechanistic model for client remodeling by the mitochondrial Hsp90, TRAP1.
    1. Neuroscience

    TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro

    Hugo Balleza-Tapia et al.
    TrpV1 receptor activation rescues cognition-relevant network dynamics in mouse hippocampus in an acute Alzheimer disease model providing a novel therapeutic target.
    1. Neuroscience

    Nucleophile sensitivity of Drosophila TRPA1 underlies light-induced feeding deterrence

    Eun Jo Du et al.
    Electron-donating nucleophilic compounds activate TRPA1 ion channels in fruit flies and mosquitoes, but not humans, making TRPA1 a promising target for insect repellants.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid

    Ximena Steinberg et al.
    Single-molecule measurement of conformational dynamics using a genetically encoded fluorescent probe suggests that the selectivity filter region of TRPV1 channels undergoes dynamic motion during agonist activation.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke

    Paulo Wagner Pires, Scott Earley
    Acute hypoxia activates TRPA1 channels in cerebral artery endothelial cells to activate an early adaptive response to reduce tissue ischemic damage through vasodilation.
    1. Neuroscience

    A zebrafish and mouse model for selective pruritus via direct activation of TRPA1

    Kali Esancy et al.
    A pain-relaying ion channel on a hypersensitive population of sensory neurons can instead elicit sensations of itch in both fish and mice when directly activated, providing a novel model of itch transduction.
    1. Cell Biology
    2. Neuroscience

    Activity and Ca2+ regulate the mobility of TRPV1 channels in the plasma membrane of sensory neurons

    Eric N Senning, Sharona E Gordon
    Channel activity is a novel regulatory mechanism for channel mobility in the plasma membrane.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity

    James R Partridge et al.
    Cytosolic and organellar Hsp90s from higher eukaryotes have evolved a variable, and environmentally responsive N-terminal extension to regulate their activity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor

    Anastasiia Stratiievska et al.
    A dual-color TIRFM study reveals a new form of inflammatory regulation, in which a lipid kinase and ion channel reciprocally regulate each other to amplify the response to painful stimuli.

Refine your results by:

Type
Research categories