Voice your concerns about research culture and research communication: Have your say in our 7th annual survey.
174 results found
    1. Structural Biology and Molecular Biophysics

    Electron cryo-microscopy structure of the canonical TRPC4 ion channel

    Deivanayagabarathy Vinayagam et al.
    Structural insights into the architecture and functional properties of zebrafish TRPC4 are revealed by high-resolution cryo-EM.
    1. Structural Biology and Molecular Biophysics

    Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

    Kangcheng Song et al.
    The binding sites of two distinct TRPC5 inhibitors clemizole and HC-070 are revealed by cryo-EM.
    1. Neuroscience

    Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels

    Sandeep Dembla et al.
    Pro-nociceptive and pro-inflammatory TRPM3 (transient receptor potential melastatin 3) channels, expressed in somatosensory neurons, are inhibited by activation of Gαi-coupled receptors, such as µ-opioid receptors, in vitro and in vivo.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms

    Siyuan Zhao et al.
    Disease-associated mutants of the TRPM3 ion channel are overactive, and they are inhibited by the antiepileptic medication primidone, offering a potential therapeutic intervention to treat this channelopathy.
    1. Structural Biology and Molecular Biophysics

    Structure of the human lipid-gated cation channel TRPC3

    Chen Fan et al.
    Cryo-EM structure reveals architecture, lipid-binding sites, and ion-conducting pore of the human TRPC3 cation channel.
    1. Structural Biology and Molecular Biophysics

    Structural basis for pharmacological modulation of the TRPC6 channel

    Yonghong Bai et al.
    Novel drug-binding sites of TRPC6 could potentially facilitate future design of drugs to treat TRPC6-mediated diseases.
    1. Structural Biology and Molecular Biophysics

    Structural basis of TRPC4 regulation by calmodulin and pharmacological agents

    Deivanayagabarathy Vinayagam et al.
    Cryo-EM structures reveal how the canonical TRPC4 cation channel is regulated by calmodulin, and how it is modulated by pyridazinone-based inhibitors.
    1. Neuroscience

    Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy

    Evelien Van Hoeymissen et al.
    Two mutations in TRPM3 resulting in developmental and epileptic encephalopathies result in a gain-of-channel function, which may lie at the basis of epileptic activity and neurodevelopmental symptoms in the patients.
    1. Neuroscience

    G protein βγ subunits inhibit TRPM3 ion channels in sensory neurons

    Talisia Quallo et al.
    TRPM3 inhibition is identified as a novel mechanism for G-protein βγ subunit signalling.
    1. Neuroscience

    TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells

    Bin Wu et al.
    Purkinje cells feature molecular heterogeneity that introduces differentiation in physiological properties between zebrin-identified cerebellar modules and thereby underlies the differential control on sensorimotor integration.

Refine your results by:

Type
Research categories