35 results found
    1. Structural Biology and Molecular Biophysics

    Conservation of the cooling agent binding pocket within the TRPM subfamily

    Kate Huffer, Matthew CS Denley ... Kenton J Swartz
    The cooling agent pocket in TRPM8 is conserved in a subset of other TRPM channels and the cooling agent icilin can regulate opening of TRPM4 channels in response to calcium and voltage.
    1. Cell Biology

    TRPγ regulates lipid metabolism through Dh44 neuroendocrine cells

    Dharmendra Kumar Nath, Subash Dhakal, Youngseok Lee
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Immunology and Inflammation

    G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs

    Yi-Hong Li, Yi-Sen Yang ... Liquan Huang
    Conditional abolishment of a G protein subunit in a subset of ectopic tuft cells engenders severer injury, slower recovery, and increased fatality following the infection of the influenza viruses.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants

    Balázs István Tóth, Bahar Bazeli ... Thomas Voets
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila

    Jayati Gera, Marishia Agard ... Meet Zandawala
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Immunology and Inflammation
    2. Neuroscience

    Neuronal NPR-15 modulates molecular and behavioral immune responses via the amphid sensory neuron-intestinal axis in C. elegans

    Benson Otarigho, Anna Frances Butts, Alejandro Aballay
    Molecular and genetics approaches reveal a dual regulatory role of neuronal G-protein-coupled receptor NPR-15 in both immunity and avoidance behavior, independent of aerotaxis, mediated by amphid sensory neurons, ASJ.
    1. Ecology
    2. Evolutionary Biology

    miR-252 targeting temperature receptor CcTRPM to mediate the transition from summer-form to winter-form of Cacopsylla chinensis

    Songdou Zhang, Jianying Li ... Xiaoxia Liu
    The first comprehensive study on the regulation mechanism of miR-252 and temperature receptor CcTRPM on insect seasonal polyphenism will also conducive to designing a new method for pest control.
    1. Neuroscience

    Neural substrates of cold nociception in Drosophila larva

    Atit A. Patel, Albert Cardona, Daniel N. Cox
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    • Incomplete
    1. Neuroscience

    Cholinergic modulation shifts the response of CA1 pyramidal cells to depolarizing ramps via TRPM4 channels with potential implications for place field firing

    Crescent L Combe, Carol M Upchurch ... Sonia Gasparini
    A nonspecific cation current mediated by TRPM4 channels is a major contributor to the increase in excitability induced by cholinergic modulation in hippocampal CA1 pyramidal neurons, which are thought to play an important role in episodic memory.
    1. Neuroscience

    Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in Drosophila

    Nathaniel J Himmel, Akira Sakurai ... Daniel N Cox
    Anoctamin/TMEM16 and SLC12 co-transporter genes selectively function in regulating cold nociception via excitatory chloride currents and can promote neuropathic sensitization phenotypes, including behavioral sensitization and neuronal hyperexcitability in Drosophila multimodal sensory neurons.
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