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The analysis of 20 coral genomic datasets provides unprecedented insights into what makes reef-building corals unique, including the evolution of novel gene families involved in biomineralization, signaling and stress responses that have led to their evolutionary success throughout the Phanerozoic Eon.

Cryo-EM structure reveals architecture, lipid-binding sites, and ion-conducting pore of the human TRPC3 cation channel.

Ligand-induced two-fold symmetric arrangement in TRPV2 is observed in the native-like nanodisc-reconstituted condition using cryo-electron microscopy.

The activation and membrane localization of the broadly-tuned noxious chemosensory cation channel TRPA1 are regulated by direct interactions with cholesterol via CRAC motifs in transmembane segments 2 and 4.

The TRPV1, TRPV2 and TRPV3 channels are gated on the cytosolic side of the pore, whereas structural changes in the ion selectivity filter associated with activation don't control cation access.

C-mannosylation supports native folding of thrombospondin type 1 repeats in the endoplasmic reticulum and stabilizes the folded proteins by modulating the dynamics of the tryptophan-arginine ladder.

The pain mediator bradykinin was found to sensitize spinal motoneurons by a direct postsynaptic action, questioning the role of motoneurons in the assessment of hyperalgesia since the withdrawal motor reflex is commonly used as a surrogate pain model.

Highly temperature-sensitive behavior of voltage-gated potassium channels provides a mechanistic model for how heat-activated TRP channels serve as temperature and pain sensors.

Natural sugars are preferred over artificial sweeteners because of their nutritional content, which is sensed by MCH neurons in the lateral hypothalamus.

Hedgehog signaling plays a role in regulating glia gene expression in planarians, pointing to a candidate ancestral and broadly used role for the Hedgehog pathway.