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The TRPV1, TRPV2 and TRPV3 channels are gated on the cytosolic side of the pore, whereas structural changes in the ion selectivity filter associated with activation don't control cation access.

Cryo-EM structure reveals architecture, lipid-binding sites, and ion-conducting pore of the human TRPC3 cation channel.

C-mannosylation supports native folding of thrombospondin type 1 repeats in the endoplasmic reticulum and stabilizes the folded proteins by modulating the dynamics of the tryptophan-arginine ladder.

Lymphatic-enriched microRNA miR-204 is required for lymphatic development through its effects on the key lymphatic transcription factor NFATC1.

Computational modeling motivated by recent experiments clarifies biophysical mechanisms generating the rhythm and amplitude of breathing at the level of neurons and brain circuits in mammals.

Ligand-induced two-fold symmetric arrangement in TRPV2 is observed in the native-like nanodisc-reconstituted condition using cryo-electron microscopy.

The molecular identity of the temperature-sensitive ion channel of human sperm that ensures depolarization is TRPV4.

A single kinetic step in the G protein activation cycle determines whether a G protein-coupled receptor activates G protein-gated K⁺ channels or not.

Temperature-activated TRPV1 ion channels respond to increased temperatures by opening and then entering an inactivated state from which they cannot recover, suggesting that this form of irreversible gating results from partial unfolding during heat absorption.

The activation and membrane localization of the broadly-tuned noxious chemosensory cation channel TRPA1 are regulated by direct interactions with cholesterol via CRAC motifs in transmembane segments 2 and 4.