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    1. Structural Biology and Molecular Biophysics

    Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates

    Iordan Iordanov et al.
    Invertebrate TRPM2 channels have stable pores but act as chanzymes that hydrolyze their activating ligand ADP ribose (ADPR), whereas vertebrate TRPM2 channels are catalytically dead but undergo pore inactivation.
    1. Neuroscience

    Sensory Neurons: A new target for G protein signaling

    László Csanády
    G protein-coupled receptor stimulation inhibits TRPM3 channel activity through direct binding of the Gβγ subunit to the channel.
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    1. Neuroscience

    Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits

    Doreen Badheka et al.
    Electrophysiological experiments, Ca2+ imaging, and behavioral studies in mice identify the TRPM3 ion channel as a novel target of G-protein βγ subunits.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

    Iordan Iordanov et al.
    TRPM2 is simply a ligand gated channel and does not to possess enzymatic activity, even though it shows sequence similarity to Nudix hydrolases.
    1. Biochemistry and Chemical Biology

    Cytokines: Revealing the secrets of secretion

    Antony Galione, Lianne C Davis
    An intracellular ion channel may have a central role in the release of cytokines by macrophages.
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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor

    Anastasiia Stratiievska et al.
    A dual-color TIRFM study reveals a new form of inflammatory regulation, in which a lipid kinase and ion channel reciprocally regulate each other to amplify the response to painful stimuli.
    1. Cell Biology

    High lumenal chloride in the lysosome is critical for lysosome function

    Kasturi Chakraborty et al.
    Lysosomes are highly enriched in chloride, which is essential for their degradative function.
    1. Cell Biology

    The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

    Wenbao Hu et al.
    XIAP/TRIP-Br1-mediated degradation of multiple adenylyl cyclase isoforms is a previously unrecognised general mechanism for controlling adenylyl cyclase expression and the homeostasis of cAMP signalling.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling

    Rajan Thakur et al.
    Phosphatidic acid regulates recycling of endocytosed plasma membrane vesicles in polarized cells through a retromer and Arf1 dependent process.