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    1. Neuroscience

    The cation channel TRPA1 tunes mosquito thermotaxis to host temperatures

    Román A Corfas, Leslie B Vosshall
    Female mosquitoes are exquisitely sensitive to human body heat, and the TRPA1 gene is required to focus their attraction toward thermal stimuli resembling warm-blooded hosts.
    1. Structural Biology and Molecular Biophysics

    Regulatory switch at the cytoplasmic interface controls TRPV channel gating

    Lejla Zubcevic et al.
    C-terminal domain of thermoTRPV channels regulates channel gating at the cytoplasmic interface through a switch-like process.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor

    Anastasiia Stratiievska et al.
    A dual-color TIRFM study reveals a new form of inflammatory regulation, in which a lipid kinase and ion channel reciprocally regulate each other to amplify the response to painful stimuli.
    1. Developmental Biology

    Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6

    Yi Xin et al.
    Genetics, in vivo imaging, and unbiased chemical biology screens reveal that Trpv6 functions as a cellular quiescence regulator and delineates a Trpv6-mediated Ca2+ signaling pathway maintaining the quiescent state.
    1. Structural Biology and Molecular Biophysics

    Irreversible temperature gating in trpv1 sheds light on channel activation

    Ana Sánchez-Moreno et al.
    Temperature-activated TRPV1 ion channels respond to increased temperatures by opening and then entering an inactivated state from which they cannot recover, suggesting that this form of irreversible gating results from partial unfolding during heat absorption.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice

    Zdravka Daneva et al.
    Endothelial pannexin 1-P2Y2 purinergic receptor-TRPV4 channel signaling, facilitated by caveolin-1, is a novel pathway for lowering pulmonary arterial pressure.
    1. Structural Biology and Molecular Biophysics

    An external sodium ion binding site controls allosteric gating in TRPV1 channels

    Andres Jara-Oseguera et al.
    Allosteric gating in a transient receptor potential channel is modulated by external sodium ions and a tarantula toxin.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut

    Chiwei Xu et al.
    In response to tissue damage, reactive oxygen species can be sensed by cation channels TRPA1/RyR to cause increases of cytosolic Ca2+ in intestinal stem cells, activating Ras/MAPK activity and stimulating stem cell proliferation in Drosophila.
    1. Structural Biology and Molecular Biophysics

    Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin

    Chanhyung Bae et al.
    The structure of a bivalent double-knot tarantula toxin bound to the outer pore of the capsaicin receptor reveals a novel mode of toxin-channel recognition that has important implications for thermosensation.
    1. Neuroscience
    2. Physics of Living Systems

    Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure

    Simon Bulley et al.
    Arterial myocyte PKD2 channels are activated by vasoconstrictor stimuli, which increases blood pressure, are upregulated during hypertension and cell-specific knockout in vivo reduces both physiological blood pressure and hypertension.