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Cryo-EM structure of a peptidase-containing ABC transporter in complex with its protein substrate reveals a mechanism of coupling substrate cleavage to translocation.

Cellular and molecular analyses reveal how Myogenin controls muscle stem cell quiescence and growth of adult muscle fibres.

LIPG, a lipoprotein lipase, executes its oncogenic function in human basal-like triple-negative breast cancer through its functional involvement in DTX3L-ISG15 signaling, an interferon-related pathway that regulates protein functionality by ISGylation.

Abolishing opposing hair cell orientation in mouse otolith and zebrafish neuromast organs preserves segregation of afferent innervation but affects zebrafish mechanotransduction and mouse vestibular reflexes.

Based on the proteomics results, T1 CRC LNM prediction models were built using machine learning, the functional differences and biomarkers between LNM-negative and LNM-positive patients were revealed.

A zebrafish model for a particular form of human deafness (DFNB63) changes our view of this disease by revealing a defect in the localization of Transmembrane channel-like proteins that are essential for mechanotransduction in sensory cells.

IQCH is required for acrosome and axoneme development during spermatogenesis in humans and mice.

Transcription factors downstream of Hippo signaling control formation of the Left-Right Organizer by regulating major signaling pathways, expression of transcription factors and regulators of epigenetic programming involved in this process.

An interdisciplinary approach combining high throughput genotype-to-phenotype mapping, population genetic simulations, and experimental evolution provides an answer to the question of how populations evolve new functions by providing tests of the role antagonistic coevolution plays in pressuring populations to innovate.

Analysis of Chlamydomonas, planaria and mice reveals a novel and unanticipated role for a peptide amidating enzyme in primary and motile ciliary assembly through effects on post-Golgi trafficking.