71 results found
    1. Developmental Biology

    Molecular conservation of marsupial and eutherian placentation and lactation

    Michael W Guernsey et al.
    The short-lived tammar wallaby placenta expresses genes resembling eutherian placentas, establishing marsupials as "placental mammals", further, dynamic lactation allows marsupials to compensate for short placentation by expressing key placental genes in the mammary gland.
    1. Developmental Biology

    Reproduction: What is a placental mammal anyway?

    Patrick Abbot, John A Capra
    Many developmental functions in marsupials and eutherian mammals are accomplished by different tissues, but similar genes.
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    1. Ecology
    Deer mouse illustration

    The Natural History of Model Organisms: Peromyscus mice as a model for studying natural variation

    Nicole L Bedford, Hopi E Hoekstra
    The deer mouse (Peromyscus) has emerged as a model system for studying many aspects of biology, supported by extensive historical knowledge of its fascinating and varied natural history.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy

    Camilla Nehammer et al.
    A microRNA prevents the accumulation of toxic proteins by inducing autophagy.
    1. Immunology and Inflammation

    Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4+ T cells tolerized by peptide immunotherapy

    Rhoanne C McPherson et al.
    Peptide immunotherapy in mice depends upon sustained expression of co-inhibitory protein PD-1 in T cells.
    1. Neuroscience

    Natural ITD statistics predict human auditory spatial perception

    Rodrigo Pavão et al.
    Human brain has incorporated natural statistics of spatial cues to the neural code supporting perception of sound location.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Bedrock radioactivity influences the rate and spectrum of mutation

    Nathanaëlle Saclier et al.
    Subterranean isopods endemic to regions with large igneous rock formations have a higher mutation rate and display an excess of mutations that are typical of an oxidative stress.
    1. Neuroscience

    Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner

    Adam J Granger et al.
    Most ChAT-expressing interneurons are a subset VIP+ interneurons that differentially release GABA and acetylcholine onto different post-synaptic targets, while a separate population of non-VIP ChAT+ neurons release acetylcholine in mPFC.
    1. Neuroscience

    A long non-coding RNA is required for targeting centromeric protein A to the human centromere

    Delphine Quénet, Yamini Dalal
    A non-coding RNA-based targeting mechanism could potentially epigenetically maintain specialized chromatin structures, such as the centromere, in vivo.
    1. Cell Biology
    2. Evolutionary Biology

    TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

    Michael Sulak et al.
    Elephants escaped enhanced cancer susceptibility by evolving more master tumor suppressor genes.

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