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Nucleosomes inside of baker’s yeast cells largely do not resemble those found in test tubes.

Knockout of the J domain protein DnaJC7 reduces tau aggregate clearance and increases intracellular tau seeding for recombinant and human brain-derived tau seed sources.

Inhibition of 5-HT neurons in the dorsal raphe nuclei or 5-HT terminals in the anterior cingulate cortex decreased consolation-like behaviors and reduced sociability.

The slope of the power spectrum of subthalamic local field potentials tracks pathological states in Parkinson’s disease and likely complements beta activity as a feedback marker for adaptive deep brain stimulation.

A female fertility syndrome in Drosophila called gonadal dysgenesis is caused by the P-transposase actively mobilizing a very short P-element variant that has been named the Har-P.

The structure of KvAP addresses a mechanism of voltage-dependent gating that has been debated for 16 years.

BIN1 forms a complex with Tau and voltage-gated calcium channels in neurons, and higher BIN1 levels promote neuronal activity, calcium influx, and bursting that is blocked by reducing Tau.

Simulations reveal where phosphoinositide lipids bind to voltage-gated sodium channels and how they reduce channel activity.

Laboratory-based methods are presented that produce filamentous tau aggregates with the same structures as those observed in neurodegenerative disease.

Structural basis and molecular mechanism of how molecular chaperone Hsp27 specifically captures phosphorylated Tau and prevents it from abnormal aggregation.