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The study of the interactions between 65,356 variants of the SARS-CoV-2 receptor binding domain and a panel of monoclonal antibodies shows that Omicron’s escape is driven by a small number of large effect mutations.

Hedgehog-pathway activation in adjacent epithelial and stromal cells, but not in epithelial or stromal cells alone, enables the generation of functional de novo hair follicles in unwounded adult mouse skin.

μCT-aided study illuminates the cranial endoskeleton and interrelationships of the Permian actinopterygian †Brachydegma, which is now excluded from crown neopterygians despite exhibiting a double jaw joint.

The giant caiman Purussaurus from the Miocene of Venezuela is the first recorded member of crown Crocodylia having three sacrals, thus breaking the otherwise strict vertebral constraint of the group.

A summary of the current “state-of-the-field” of single-molecule FRET used for probing biomolecular structural dynamics.

Hexosamine salvage through the enzyme N-acetylglucosamine kinase is stimulated in nutrient-limited conditions and supports pancreatic tumor growth.

Functional molecular analysis of cytokinesis in Caenorhabditis elegans four-cell embryos reveals cell-type-specific variation in the fundamental dependence on a robust f-actin cytoskeleton for successful cell division, mediated by both cell-intrinsic and -extrinsic pathways.

A nuclear Non-stop identity complex (NIC) supervises enterocyte (EC) identity, preserves tissue homeostasis, and prevents premature aging by maintaining EC-specific gene expression, silencing non-relevant programs, and safeguarding large-scale nuclear organization.

An unrecognized regulation on MAGEA protein stability promotes pancreatic cancer progression via manipulating autophagy and may impact the clinical utility of MAGEA-targeted immunotherapy.

Of the 50 primary olfactory channels in vinegar flies, only 10 drive avoidance or approach behavior when activated by themselves, indicating that most olfactory responses are multi-channel responses that follow complex combination rules.