Purine recycling deficiency triggers metabolic and neurological defects reminiscent of Lesch–Nyhan disease in Drosophila, paving the way for studying this disorder and carrying out drug screening in an invertebrate organism.
Progressive changes in Purkinje neuron perturbations and overall cerebellar atrophy correlate for the first time with the development of an overt loss of motor function in a novel mouse model of Ataxia Telangiectasia.
Adaptations in protein synthesis and mRNA surveillance machinery enabled the malaria-causing parasite P. falciparum to efficiently and accurately translate long polyA nucleotide runs into long poly-lysine peptides.
A novel molecular mechanism linking a neurotrophin with a Toll-family and kinase-less Trk-like receptors provides a direct link from molecules to structural circuit plasticity and modification of behaviour.
Samuel Frederick Mock Hart, Jose Mario Bello Pineda ... Wenying Shou
Whereas partner-serving phenotype is intuitively quantified as benefit release rate, molecular genetics revealed an example where this thinking fails, motivating a more general metric.
The C terminal fusion partners of TAZ-CAMTA1, YAP-TFE3 and potentially other TAZ/YAP fusion proteins in cancer recruit epigenetic modifiers that modulate a baseline TEAD-based transcriptional program.
