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    1. Neuroscience

    Astrocyte aquaporin mediates a tonic water efflux maintaining brain homeostasis

    Cuong Pham, Yuji Komaki ... Dongdong Li
    The water channel AQP4 contributes to a tonic water outflow from brain astrocytes, thereby modulating their volume dynamics and the ambient water homeostasis.
    1. Cell Biology

    The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15)

    Ilja Vietor, Domagoj Cikes ... Lukas A Huber
    Ifrd1 and Ifrd2 were identified using knockout mice as new molecular players regulating via two discrete mechanisms the activity of the transcriptional regulator Dlk1 and thereby affecting adipocyte differentiation.
    1. Cell Biology
    2. Computational and Systems Biology

    Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

    Christopher Edelmaier, Adam R Lamson ... Meredith D Betterton
    A computational model of fission yeast mitosis can interrogate mechanisms required for successful mitosis, the origin of spindle length fluctuations, and spindle force balance during assembly.
    1. Chromosomes and Gene Expression

    HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells

    Jonathan E Reeder, Youn-Tae Kwak ... Iván D'Orso
    Tat uses unexpected regulatory mechanisms to reprogram target immune cells to promote viral replication and rewire pathways beneficial for HIV.
    1. Computational and Systems Biology
    2. Neuroscience

    Sex differences in learning from exploration

    Cathy S Chen, Evan Knep ... Nicola M Grissom
    A new computational analysis of decision making in mice shows sex biases in value-updating while exploring unknown options, with male mice tending to explore longer than females due to updating values more slowly.
    1. Neuroscience

    Gaze patterns and brain activations in humans and marmosets in the Frith-Happé theory-of-mind animation task

    Audrey Dureux, Alessandro Zanini ... Stefan Everling
    Shared traits in gaze patterns and brain activations between marmosets and humans during Theory of Mind animations reveal cross-species cognitive similarities.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years

    Mickaël De Carvalho, Guo-Song Jia ... Sarah E Zanders
    The wtf family of meiotic drivers has maintained the capacity to cause meiotic drive for over 100 million years.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Effective dynamics of nucleosome configurations at the yeast PHO5 promoter

    Michael Roland Wolff, Andrea Schmid ... Ulrich Gerland
    The integration of multi-nucleosome configuration data with histone turnover and new chromatin accessibility data by systematically investigated 'regulated on-off-slide' models reveals promoter state transitions regulated by just one assembly process.
    1. Computational and Systems Biology

    Spatiotemporal establishment of dense bacterial colonies growing on hard agar

    Mya R Warren, Hui Sun ... Terence Hwa
    A 3D model captures the growth and expansion dynamics of bacterial colonies, revealing distinct effects of surface tension, mechanical forces, and nutrients on the speed of radial and vertical expansion.
    1. Cancer Biology

    The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells

    Jie Fang, Shivendra Singh ... Jun Yang
    Not revised
    Reviewed Preprint v1
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