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A telomerase recruitment mechanism delivers cell cycle information to the telomere-telomerase interface to ensure timely telomerase engagement at the telomere.

Two methyl-binding domain proteins have interdependent functions in embryonic stem cells, and this interdependency extends to the DNA methylation/hydroxymethylation machinery.

Cell-specific alternative splicing of the synaptic calcium channel gene Cacna1b is controlled by exon hypomethylation and CTCF binding and is disrupted following nerve injury.

Peptide immunotherapy in mice depends upon sustained expression of co-inhibitory protein PD-1 in T cells.

The ZF-CxxC protein FBXL19 recruits kinase-associated Mediator to CpG islands of silent developmental genes in embryonic stem cells, which primes these genes for activation during differentiation and is required for embryonic development.

Cdc13 prevents chromosomes from end-to-end fusion.

Telomeric proteins Taz1 or Mit1 specifically regulate telomere association of condensin which is essential for sister-telomere disjunction in mitosis by restraining telomere association of cohesin.

A new gene expression tool enables precise control of protein dosage over a large range and paves the way for new genetic discoveries.

PCGF6 links sequence specific target recognition by the MAX/MGA transcription factor complex to PRC1 (polycomb repressive complex 1) -dependent transcriptional silencing of germ cell-specific genes in mouse pluripotent stem cells.