20 results found
    1. Biochemistry
    2. Cell Biology

    Sorting of a multi-subunit ubiquitin ligase complex in the endolysosome system

    Xi Yang et al.
    A single transmembrane E3 ligase complex can regulate protein ubiquitination at multiple organelles using interchangeable targeting subunits.
    1. Genomics and Evolutionary Biology

    The last common ancestor of animals lacked the HIF pathway and respired in low-oxygen environments

    Daniel B Mills et al.
    Sponges and ctenophores lack hypoxia-inducible factors, suggesting that the metazoan last common ancestor could have lived aerobically under severe hypoxia and did not need to regulate its transcription in response to oxygen availability.
    1. Genomics and Evolutionary Biology

    Evolution: Oxygen and early animals

    Kalle T Rytkönen
    The biology of sponges provides clues about how early animals may have dealt with low levels of oxygen.
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    1. Developmental Biology and Stem Cells
    2. Genes and Chromosomes

    ME31B globally represses maternal mRNAs by two distinct mechanisms during the Drosophila maternal-to-zygotic transition

    Miranda Wang et al.
    ME31B is a general repressor of gene expression in the Drosophila early embryo, repressing translation before the maternal-to-zygotic transition and stimulating mRNA decay after activation of the zygotic genome.
    1. Immunology

    Na+ influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation

    Yong Miao et al.
    Non-specific sodium entry inhibits T cell receptor induced gene expression and differentiation of T cells by depleting intracellular ATP and disrupting mTORC2 dependent signalling axis.
    1. Biophysics and Structural Biology
    2. Cell Biology

    Electrostatic anchoring precedes stable membrane attachment of SNAP25/SNAP23 to the plasma membrane

    Pascal Weber et al.
    A step of contact establishment preceding stable membrane attachment by palmitoylation is identified.
    1. Biophysics and Structural Biology
    2. Microbiology and Infectious Disease

    Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis

    Blessy Paul et al.
    Chlamydia hijacks membrane trafficking proteins of the human host via the cytoplasmic domain of a secreted transmembrane protein.
    1. Cell Biology

    YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB

    Gisela Schimmack et al.
    The deubiquitinating enzyme YOD1 binds to the E3 ligase TRAF6 to counteract p62/sequestosome1 mediated pro-inflammatory NF-κB signaling in response to interleukin-1.
    1. Neuroscience
    2. Developmental Biology and Stem Cells

    Neuroendocrine modulation sustains the C. elegans forward motor state

    Maria A Lim et al.
    RID is a descending peptidergic neuron that sustains the forward motor state.
    1. Cancer Biology
    2. Developmental Biology and Stem Cells

    Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit

    Julia Hatzold et al.
    A Na,K-ATPase beta subunit can suppress basal cell carcinogenesis either via its osmoregulatory function to avoid hypotonic stress, or by promoting epithelial polarity and adhesiveness of basal keratinocytes from the overlying outer layer.

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